{
  "abstract": "This study aimed to produce and characterize nanofiber membranes (PLGA/HA@LMWH) containing Poly(lactic-co-glycolic acid)/Hyaluronic Acid (PLGA/HA) immobilized with low-molecular-weight heparin (LMWH), and to investigate their physical and chemical effects in preventing intraabdominal adhesions in a rat model using multidisciplinary methods. Forty female Wistar Albino rats were divided into four groups (n = 10). Cecal abrasions were induced in three groups: treated with PLGA/HA membrane, PLGA/HA@LMWH membrane, and 0.9% NaCl (SS). The fourth group underwent laparotomy only. On day 21, rats were sacrificed and evaluated macroscopically, histopathologically, immunohistochemically, and biochemically. Macroscopic adhesion, inflammation, fibrosis, neovascularization, collagen scores, and TGF-β1 expression were found to be high in the SS and PLGA/HA groups, while a significant decrease (p < 0.05-0.01) was detected in all of these values in the PLGA/HA@LMWH group. NF-κB activation was significantly decreased in the PLGA/HA and especially the PLGA/HA@LMWH groups compared to the SS group (p < 0.05). In addition, apoptosis was suppressed in the PLGA/HA@LMWH group, with increased Bcl-2 and decreased cleaved caspase-3. The PLGA/HA@LMWH membrane reduced peritoneal adhesions by suppressing inflammation, fibrosis, neovascularization, and collagen deposition, lowering TGF-β1 expression and NF-κB and p-NF-κB levels, and suppressing apoptosis. However, large-scale studies are needed for clinical use.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anatomy, Faculty of Medicine, Inonu University, Malatya 44050, Türkiye.",
    "Department of Medical Biochemistry, Faculty of Medicine, Inonu University, Malatya 44050, Türkiye.",
    "Department of Chemistry, Faculty of Arts and Sciences, Inonu University, Malatya 44050, Türkiye.",
    "Department of Pathology, Faculty of Veterinary Medicine, Fırat University, Elazığ 23119, Türkiye.",
    "Department of Radiology, Faculty of Medicine, Inonu University, Malatya 44050, Türkiye.",
    "Department of Anatomy, Faculty of Medicine, Malatya Turgut Özal University, Malatya 44210, Türkiye.",
    "Department of Family Medicine, Faculty of Medicine, Inonu University, Malatya 44050, Türkiye.",
    "Department of Medical History and Ethics, Faculty of Medicine, Inonu University, Malatya 44050, Türkiye.",
    "Faculty of Dentistry, Bingöl University, Bingöl 12000, Türkiye."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Turgay Karatas"
    },
    {
      "affs": [
        1
      ],
      "name": "Nurcan Gokturk"
    },
    {
      "affs": [
        2
      ],
      "name": "Kubra Karadas Gedik",
      "orcid": "0000-0002-2310-2937"
    },
    {
      "affs": [
        3
      ],
      "name": "Burak Karabulut",
      "orcid": "0000-0002-4907-6159"
    },
    {
      "affs": [
        0
      ],
      "name": "Damla Bilge Tasdemir",
      "orcid": "0000-0002-5247-9864"
    },
    {
      "affs": [
        4
      ],
      "name": "Mehmet Akif Turkoz"
    },
    {
      "affs": [
        2
      ],
      "name": "Ahmet Ulu",
      "orcid": "0000-0002-4447-6233"
    },
    {
      "affs": [
        1
      ],
      "name": "Yusuf Turkoz",
      "orcid": "0000-0001-5401-0720"
    },
    {
      "affs": [
        3
      ],
      "name": "Necati Timurkaan"
    },
    {
      "affs": [
        2
      ],
      "name": "Tugba Dogan",
      "orcid": "0000-0002-3264-9467"
    },
    {
      "affs": [
        5
      ],
      "name": "Anıl Kaya"
    },
    {
      "affs": [
        6
      ],
      "name": "Engin Burak Selcuk"
    },
    {
      "affs": [
        7
      ],
      "name": "Mehmet Karatas",
      "orcid": "0000-0002-9093-6456"
    },
    {
      "affs": [
        8
      ],
      "name": "Meryem Budak"
    },
    {
      "affs": [
        2
      ],
      "name": "Burhan Ates"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4gbkh3p3mkynx.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27198715",
  "fulltext_url": "https://europepmc.org/articles/PMC13665143",
  "id": "4gbkh3p3mkynx",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://europepmc.org/article/MED/42883959",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Intestinal and Peritoneal Adhesions"
    ]
  ],
  "openalex": "W7214757104",
  "pdf_url": "https://europepmc.org/articles/PMC13665143?pdf=render",
  "pmcid": "PMC13665143",
  "pmid": "42883959",
  "published": "2026-09-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4gbkh3p3mkynx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42883959",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42883959"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Intestinal and Peritoneal Adhesions",
      "subfield": "surgery"
    }
  ],
  "title": "Multimodal Evaluation of the Anti-Adhesion Effects of Heparin-Loaded PLGA/HA Nanofiber Membranes in an Intraperitoneal Adhesion Model in Rats.",
  "title_text": "Multimodal Evaluation of the Anti-Adhesion Effects of Heparin-Loaded PLGA/HA Nanofiber Membranes in an Intraperitoneal Adhesion Model in Rats.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/4gbkh3p3mkynx",
  "venue": "International journal of molecular sciences",
  "versions": []
}