{
  "abstract": "Methamphetamine use disorder (MUD) poses a significant global health challenge, lacking FDA-approved pharmacotherapies. Despite extensive exploration of therapeutic targets and interventions, effective treatment remains scarce due to challenges in delivering therapeutic agents to relevant brain regions at effective concentrations. Nanoparticle-mediated delivery offers a promising approach for transporting various therapeutic cargos to the central nervous system, including small molecules, nucleic acids, peptides, proteins, and gene-editing systems. However, the application of nanomedicine strategies in addressing the unique pathophysiological characteristics of MUD has not been systematically assessed. This review presents a problem-focused analysis of how lipid-based, polymeric, inorganic, biological, and hybrid nanocarriers tackle successive delivery obstacles such as systemic stability, blood-brain barrier (BBB) penetration, brain region-specific distribution, and controlled release of intracellular cargo. We compare preclinical nanotherapeutic approaches encompassing small-molecule neuroprotective agents, anti-METH vaccines, gene-silencing RNAs, neurotrophic proteins, and emerging gene-editing methods, outlining their respective benefits, limitations, and design considerations. Additionally, we explore key factors influencing nanomedicine performance in MUD, including protein corona formation, the impact of METH-related BBB dysfunction and neuroinflammation on nanoparticle distribution, and the disparity between acute animal models and chronic human MUD with relapse tendencies. In conclusion, we present a systematic framework for aligning nanocarrier characteristics with distinct delivery obstacles and therapeutic needs. We also emphasize forthcoming avenues such as disease-triggered nanocarriers, targeted delivery to specific regions, combined nanomedical approaches, theranostic strategies, and standardized assessments of biodistribution, effectiveness, safety, and translational potential.",
  "abstract_shown": true,
  "affiliations": [
    "NHC Key Laboratory of Drug Addiction Medicine, School of Forensic Medicine, Kunming Medical University, Kunming, Yunnan, 650500, People's Republic of China.",
    "Faculty of Information Engineering and Automation, Kunming University of Science and Technology, Kunming, Yunnan, 650500, People's Republic of China."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xinjie Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Ruike Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Min Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Yan Du"
    },
    {
      "affs": [
        1
      ],
      "name": "Miao Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Lihua Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Genmeng Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Shijun Hong"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4gdzgny23vk1e.bib",
  "cited_by": 0,
  "doi": "10.2147/ijn.s625117",
  "fulltext_url": "https://europepmc.org/articles/PMC13679526",
  "id": "4gdzgny23vk1e",
  "issns": [
    "1176-9114",
    "1178-2013"
  ],
  "landing_url": "https://europepmc.org/article/MED/42899172",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2502|Nanoparticle-Based Drug Delivery"
    ]
  ],
  "openalex": "W7221835704",
  "pdf_url": "https://europepmc.org/articles/PMC13679526?pdf=render",
  "pmcid": "PMC13679526",
  "pmid": "42899172",
  "published": "2026-10-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4gdzgny23vk1e.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:33Z",
      "native_id": "MED:42899172",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42899172"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Nanoparticle-Based Drug Delivery",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Nanoparticle-Mediated Brain-Targeted Drug Delivery for Methamphetamine Use Disorder: Advances, Challenges and Translational Perspectives.",
  "title_text": "Nanoparticle-Mediated Brain-Targeted Drug Delivery for Methamphetamine Use Disorder: Advances, Challenges and Translational Perspectives.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:33Z",
  "url": "https://research.draconitic.com/paper/4gdzgny23vk1e",
  "venue": "International journal of nanomedicine",
  "versions": []
}