{
  "abstract": "BackgroundGastrointestinal (GI) motility disorders are prevalent, impose a significant burden, and are associated with disrupted spatial propagation of bioelectrical gastric slow waves. High-resolution endoscopic gastric mapping (EGM) is an emerging minimally invasive technique for imaging gastric electrical activity; however, EGM is performed alongside standard gastroscopy and requires procedural sedation, which may interact with gastric electrical activity, distorting clinical insights. This study explored the influence of procedural sedation on EGM-recorded slow-wave activity.\n\nMethodsEGM was performed for [~]7 min in 32 patients undergoing upper GI endoscopy at two New Zealand hospitals. Endoscopists administered procedural sedation (fentanyl and midazolam) according to best clinical practice. The relationship between slow-wave amplitude and patient characteristics was then investigated using a variety of statistical techniques.\n\nKey ResultsGastric slow waves were detected in 30 of 32 patients who underwent EGM. Symptom scores and demographic measures were comparable between sites. Fentanyl (A, 93.4 {+/-} 13.7 g vs B, 137.5 {+/-} 33.7 g, p[≤]0.001) and midazolam (A, 5.0 {+/-} 0.9 mg vs B, 7.4 {+/-} 1.6 mg, p[≤]0.001) doses were higher at Hospital B than Hospital A. Correspondingly, slow-wave amplitudes were lower at Hospital B than Hospital A (A, 2.33 {+/-} 1.61 mV vs B, 0.86 {+/-} 1.01 mV, p=0.004). All other slow-wave metrics were consistent between hospitals. Combined sedative dose was negatively correlated with slow-wave amplitude (p=0.037).\n\nConclusions & InferencesHigher procedural sedative doses are associated with lower-amplitude gastric slow-waves. Procedural sedation dose and opiate administration should be carefully considered when interpreting GI electrophysiology measurements.",
  "abstract_shown": true,
  "affiliations": [
    "The University of Auckland"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "P. Tremain"
    },
    {
      "name": "J. Dowrick"
    },
    {
      "name": "C.-H. A. Chan"
    },
    {
      "name": "D. Rowbotham"
    },
    {
      "name": "G. Lim"
    },
    {
      "name": "G. O'Grady"
    },
    {
      "name": "L. K. Cheng"
    },
    {
      "name": "J. Mckeage"
    },
    {
      "affs": [
        0
      ],
      "name": "T. R. Angeli-Gordon"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4gpsvhkcfmzac.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.15.26365429",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.10.15.26365429v1.full",
  "id": "4gpsvhkcfmzac",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.10.15.26365429v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "gastroenterology"
    ],
    [
      "openalex",
      "2715|Gastrointestinal motility and disorders"
    ]
  ],
  "openalex": "W7223012756",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.10.15.26365429v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4gpsvhkcfmzac.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "10.64898/2026.10.15.26365429",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.10.15.26365429v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:gastroenterology",
      "subfield": "general"
    }
  ],
  "title": "Sedatives reduce human gastric slow-wave amplitude, assessed by a multicenter study of endoscopic gastric mapping",
  "title_text": "Sedatives reduce human gastric slow-wave amplitude, assessed by a multicenter study of endoscopic gastric mapping",
  "type": "preprint",
  "updated_at": "2026-10-30T12:21:18Z",
  "url": "https://research.draconitic.com/paper/4gpsvhkcfmzac",
  "venue": "medRxiv",
  "versions": []
}