{
  "abstract": "线粒体-脂滴偶联(mitochondria-lipid droplet coupling，MLC)是连接细胞内脂质储存与能量代谢利用的核心结构。肥胖发生、发展的核心机制在于能量摄入与消耗失衡，而MLC在调控脂质动员、脂肪酸氧化及脂肪组织产热中发挥关键作用，但其分子机制及临床转化价值尚待阐明。MLC的功能具有双重性，在不同细胞类型或代谢状态下，特定偶联蛋白复合物介导的互作可分别导向脂肪酸氧化或脂质合成。研究表明，MLC及脂滴周边线粒体(peridroplet mitochondria，PDM)不仅通过加速脂滴分解与脂肪酸定向转运参与脂质动员，更是维持脂肪组织非颤抖性产热、提升能量消耗的关键节点。未来研究应进一步阐明不同蛋白复合物介导MLC代谢功能特异性的分子机制，并探索其在脂肪组织中的具体作用，有望为改善肥胖及相关代谢紊乱提供靶向MLC的新治疗策略。",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "name": "婉婷 郑",
      "orcid": "0009-0004-4440-7432"
    },
    {
      "name": "毅 龙"
    },
    {
      "name": "丽娜 杨",
      "orcid": "0000-0002-9503-3344"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4gt0fcd6dr7p6.bib",
  "cited_by": 0,
  "doi": "10.11817/j.issn.1672-7347.2026.260268",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710884/",
  "id": "4gt0fcd6dr7p6",
  "issns": [
    "1672-7347"
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  "landing_url": "https://doi.org/10.11817/j.issn.1672-7347.2026.260268",
  "language": "zh",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Reviews"
    ],
    [
      "openalex",
      "1303|Lipid metabolism and biosynthesis"
    ]
  ],
  "openalex": "W7223993415",
  "pdf_url": null,
  "pmcid": "PMC13710884",
  "pmid": "42935206",
  "published": "2026-08-28",
  "publisher": "Central South University",
  "ris": "https://research.draconitic.com/paper/4gt0fcd6dr7p6.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:45Z",
      "native_id": "PMC13710884",
      "source": "pmc",
      "url": "https://doi.org/10.11817/j.issn.1672-7347.2026.260268"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1303|Lipid metabolism and biosynthesis",
      "subfield": "enzymology-metabolism"
    }
  ],
  "title": "线粒体-脂滴偶联及其调控脂质代谢与肥胖的研究进展",
  "title_text": "线粒体-脂滴偶联及其调控脂质代谢与肥胖的研究进展",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:45Z",
  "url": "https://research.draconitic.com/paper/4gt0fcd6dr7p6",
  "venue": "Journal of Central South University Medical Sciences",
  "versions": []
}