{
  "abstract": "There is a rapid increase in early onset CRC worldwide. This incidence is profoundly influenced by biological aging in the colon, yet the underlying mechanisms remain incompletely defined. This review critically evaluates evidence supporting proposed interactions among telomere dynamics, sirtuins, and mitochondrial biomarkers during colon aging and as CRC risk predictors, while highlighting areas where mechanistic validation remains limited. This insight paves the way for novel early-detection biomarkers, personalized preventive approaches, and treatments designed to directly interfere with aging mechanisms and CRC risk.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medical Microbiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, Nelson R. Mandela Medical School Campus, University of KwaZulu-Natal, Durban 4001, South Africa",
    "Division of Research Capacity Development (RCD), South African Medical Research Council (SAMRC), Tygerberg, Cape Town 7505, South Africa",
    "Department of Biomedical Sciences, Faculty of Natural Sciences, Mangosuthu University of Technology, Umlazi, Durban 4031, South Africa",
    "Internal Medicine, Clinical Medicine, Faculty of Health Sciences, University of Witwatersrand, Johannesburg 2017, South Africa",
    "Department of Surgery, University of KwaZulu Natal, Durban 4001, South Africa",
    "Biomedical Sciences Department, School of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa, Florida Campus, Johannesburg 1710, South Africa"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Engelinah Dikeledi Macamo"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Pragalathan Naidoo",
      "orcid": "0000-0002-8905-5926"
    },
    {
      "affs": [
        0
      ],
      "name": "Sibusiso Senzani"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Khethiwe Nomcebo Bhengu",
      "orcid": "0000-0003-2393-3519"
    },
    {
      "affs": [
        4
      ],
      "name": "Sayed Shakeel Kader",
      "orcid": "0000-0002-6216-5703"
    },
    {
      "affs": [
        0,
        1,
        5
      ],
      "name": "Zilungile Lynette Mkhize-Kwitshana"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4h024xb4zzpem.bib",
  "cited_by": 0,
  "doi": "10.3390/cells15211994",
  "fulltext_url": null,
  "id": "4h024xb4zzpem",
  "issns": [
    "2073-4409"
  ],
  "landing_url": "https://www.mdpi.com/2073-4409/15/21/1994",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-31",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/4h024xb4zzpem.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T00:24:04Z",
      "native_id": "10.3390/cells15211994",
      "source": "crossref",
      "url": "https://www.mdpi.com/2073-4409/15/21/1994"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:2073-4409",
      "subfield": "cell-biology"
    }
  ],
  "title": "Proposed Interactions and Crosstalk Among Biological Aging Biomarkers (Telomere Length, Telomerase, Sirtuins, mtDNA Copy Number and mtDNA Methylation Levels) and Their Potential Role in Colorectal Cancer Risk: A Review",
  "title_text": "Proposed Interactions and Crosstalk Among Biological Aging Biomarkers (Telomere Length, Telomerase, Sirtuins, mtDNA Copy Number and mtDNA Methylation Levels) and Their Potential Role in Colorectal Cancer Risk: A Review",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T00:24:56Z",
  "url": "https://research.draconitic.com/paper/4h024xb4zzpem",
  "venue": "Cells",
  "versions": []
}