{
  "abstract": "This study evaluated a novel, audio-based digital monitoring system for detecting retching and vomiting (expulsion) events in a noninterventional, longitudinal study in 25 participants with gastroparesis (GP). Participants used an audio-based system comprising an iOS device (iPhone) and Watch in their homes for 14 days. Retching and expulsion events were quantified using human-annotated counts from audio recordings and daily electronic patient-reported outcome (ePRO) counts. Device compliance was calculated as recorded h divided by the total h (24 × 14). Compliance was high: 83.4% for the iPhone and 69.4% for the Watch. Event timing analyses from the audio devices revealed elevated retching and expulsion activity in the morning, with symptoms persisting during nighttime h. Watch and iOS event counts showed strong correlation (r > 0.85), though device agreement with ePRO counts was lower (r < 0.68). While ePRO-based expulsion counts showed stronger within-participant correlation with patient global impression of frequency/severity (PGI-F/PGI-S) measures, device counts better distinguished participants across PGI-F/PGI-S levels. Weekly averaging of event counts improved consistency across both audio-based and ePRO measures relative to daily event counts. Preliminary findings suggest audio-based technologies may provide an objective approach to detecting vomiting and retching, with future automation needed to support scalable implementation.",
  "abstract_shown": true,
  "affiliations": [
    "Takeda Development Center Americas Inc.",
    "Takeda Pharmaceuticals U.S.A. Inc.",
    "University of Melbourne",
    "Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yishu Gong"
    },
    {
      "affs": [
        0
      ],
      "name": "Jasmin Imsirovic"
    },
    {
      "affs": [
        0
      ],
      "name": "Brian Tracey"
    },
    {
      "affs": [
        0
      ],
      "name": "Nicholas Stylopoulos"
    },
    {
      "affs": [
        0
      ],
      "name": "Yanwei Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Muna Tahir"
    },
    {
      "affs": [
        0
      ],
      "name": "Jing Yuan"
    },
    {
      "affs": [
        1
      ],
      "name": "Xuefang Wu"
    },
    {
      "affs": [
        2
      ],
      "name": "Lisa Graf"
    },
    {
      "affs": [
        2
      ],
      "name": "Thayabaran Kathiresan"
    },
    {
      "affs": [
        2
      ],
      "name": "Adam P. Vogel"
    },
    {
      "affs": [
        3
      ],
      "name": "David J. Levinthal"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4h6020j0yxzre.bib",
  "cited_by": 0,
  "doi": "10.1038/s44355-026-00086-8",
  "fulltext_url": "https://doi.org/10.1038/s44355-026-00086-8",
  "id": "4h6020j0yxzre",
  "issns": [
    "3004-9806"
  ],
  "landing_url": "https://doi.org/10.1038/s44355-026-00086-8",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC799-869"
    ],
    [
      "openalex",
      "2715|Gastrointestinal motility and disorders"
    ]
  ],
  "openalex": "W7140828061",
  "pdf_url": "https://www.nature.com/articles/s44355-026-00086-8.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-08",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/4h6020j0yxzre.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T14:20:55Z",
      "native_id": "073a4a6d2f824113aa333591ba7841a0",
      "source": "doaj",
      "url": "https://doi.org/10.1038/s44355-026-00086-8"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2715|Gastrointestinal motility and disorders",
      "subfield": "general"
    }
  ],
  "title": "Evaluation of an audio-based monitoring system for detecting retching and vomiting in gastroparesis: an observational cohort study",
  "title_text": "Evaluation of an audio-based monitoring system for detecting retching and vomiting in gastroparesis: an observational cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T14:21:15Z",
  "url": "https://research.draconitic.com/paper/4h6020j0yxzre",
  "venue": "npj Gut and Liver",
  "versions": []
}