{
  "abstract": "Background and aim Vonoprazan, a potassium-competitive acid blocker (PCAB), has emerged as an alternative to proton pump inhibitors (PPIs) for Helicobacter pylori eradication. This study assessed the comparative effectiveness of vonoprazan- versus dexlansoprazole-based regimens in a real-world clinical setting. Methods We retrospectively analyzed 146 patients (73 per group) receiving vonoprazan- or dexlansoprazole-based therapy. Eradication success rates were compared using both frequency-based and Bayesian methods, with additional risk estimates and time-to-event analyses. Results The vonoprazan group had a higher eradication rate (93.15%, 95% CI: 84.95, 97.04) compared with dexlansoprazole (83.56%, 95% CI: 73.43, 90.34); this difference did not reach statistical significance at the conventional 0.05 level (χ² = 3.262, p = 0.07). Risk ratio (1.11, 90% CI: 1.01, 1.23) and odds ratio (2.68, 90% CI: 1.06, 6.73) estimates using exploratory 90% CIs excluded the null at this wider, non-confirmatory threshold, favoring vonoprazan, though the corresponding 95% CIs remained inconclusive. Bayesian analysis yielded a posterior risk difference of 9.3% (95% credible interval: -1.1, 20.1) and a 96.2% posterior probability that vonoprazan was more effective, though the credible interval still included values close to and below zero. Kaplan-Meier analysis showed a shorter median time to documented confirmation of eradication with vonoprazan (97 days) than with dexlansoprazole (114 days; log-rank p = 0.02), which reflects the timing of documented testing rather than a direct measure of biological eradication speed. Conclusions Vonoprazan was associated with a numerically higher eradication rate and earlier documented confirmation of eradication compared with dexlansoprazole. While the primary comparison did not reach statistical significance at the 95% level, several exploratory analyses, including the 90% CIs and the Bayesian posterior probability, were directionally consistent with a possible advantage for vonoprazan; these findings are hypothesis-generating rather than confirmatory. Larger, multicenter, prospective studies are warranted to confirm these results.",
  "abstract_shown": true,
  "affiliations": [
    "Gastroenterology, VGM Hospital, Coimbatore, IND."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Vg Mohan Prasad"
    },
    {
      "affs": [
        0
      ],
      "name": "Vamsi Murthy K"
    },
    {
      "affs": [
        0
      ],
      "name": "Madhura Prasad Suman"
    },
    {
      "affs": [
        0
      ],
      "name": "Mithra Prasad"
    },
    {
      "affs": [
        0
      ],
      "name": "Jackson Keefer Jerry"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4hjd3s7rn33nt.bib",
  "cited_by": 0,
  "doi": "10.7759/cureus.117041",
  "fulltext_url": "https://europepmc.org/articles/PMC13714520",
  "id": "4hjd3s7rn33nt",
  "issns": [
    "2168-8184"
  ],
  "landing_url": "https://europepmc.org/article/MED/42953079",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Gastroenterology"
    ],
    [
      "openalex",
      "2746|Helicobacter pylori-related gastroenterology studies"
    ]
  ],
  "openalex": "W7214645541",
  "pdf_url": "https://europepmc.org/articles/PMC13714520?pdf=render",
  "pmcid": "PMC13714520",
  "pmid": "42953079",
  "published": "2026-09-27",
  "publisher": "Cureus Inc.",
  "ris": "https://research.draconitic.com/paper/4hjd3s7rn33nt.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:41Z",
      "native_id": "MED:42953079",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42953079"
    },
    {
      "first_seen": "2026-11-01T12:22:00Z",
      "native_id": "PMC13714520",
      "source": "pmc",
      "url": "https://doi.org/10.7759/cureus.117041"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Helicobacter pylori-related gastroenterology studies",
      "subfield": "surgery"
    }
  ],
  "title": "Comparative Analysis of Vonoprazan- and Dexlansoprazole-Based Therapies for Helicobacter pylori Eradication: A Single-Center Retrospective Observational Study.",
  "title_text": "Comparative Analysis of Vonoprazan- and Dexlansoprazole-Based Therapies for Helicobacter pylori Eradication: A Single-Center Retrospective Observational Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:00Z",
  "url": "https://research.draconitic.com/paper/4hjd3s7rn33nt",
  "venue": "Cureus",
  "versions": []
}