{
  "abstract": "Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently emerged and is responsible for coronavirus disease 19 (COVID-19). Diagnostic tests have been developed, mainly based on reverse-transcriptase PCR (RT-PCR). Most RT-PCR assays target at least two SARS-CoV-2 genes. In some cases, only one target gene is detected; the interpretation of such cases remains unclear. Objectives: Our objective was to analyse one target positive (OPT) RT-PCR results, using two RT-PCR assays: the Xpert® Xpress SARS-CoV-2 (Cepheid diagnosis, \"Cepheid\") and the Cobas® 6800 SARS-CoV-2 Test (Roche Molecular Diagnostics, \"Roche\"). Methods: All SARS-CoV-2 RT-PCR results performed on respiratory samples with the Roche or the Cepheid tests, from 23rd March to 6th August 2020 were collected. A patient with an OPT result was classified as \"probable COVID-19\" if they met at least one of the three following criteria: (i) history of a two gene-positive SARS-CoV-2 RT-PCR result, (ii) anti-SARS-CoV-2 antibody (IgG) detection or (iii) compatible chest computed tomography scan (CT-scan). Results: A total of 18,630 and 1189 SARS-CoV-2 RT-PCR tests were performed with the Roche and Cepheid tests, respectively. Among the positive SARS-CoV-2 RT-PCR, 293 samples - corresponding to 264 patients - were OPT (11% of the positive samples). Of these patients, 180 (68%) had at least one of the three criteria listed above and were classified as probable COVID-19. Conclusions: Sixty-eight percent of the patients with an OPT result were classified as probable COVID-19 and are probably at a late stage of infection. Serology and imaging can be helpful to confirm diagnosis.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "name": "Honorine Fenaux"
    },
    {
      "name": "Théo Ghelfenstein-Ferreira"
    },
    {
      "name": "Maud Salmona"
    },
    {
      "name": "Nadia Mahjoub"
    },
    {
      "name": "Linda Feghoul"
    },
    {
      "name": "Sarah Maylin"
    },
    {
      "name": "Marie-Laure Chaix"
    },
    {
      "name": "Marine Minier"
    },
    {
      "name": "Audrey Gabassi"
    },
    {
      "name": "Jérôme Le Goff"
    },
    {
      "name": "Constance Delaugerre"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4hs96mfyscx4c.bib",
  "cited_by": 7,
  "doi": "10.1016/j.jcvp.2021.100021",
  "fulltext_url": null,
  "id": "4hs96mfyscx4c",
  "issns": [
    "2667-0380",
    "2667-0380"
  ],
  "landing_url": "https://hal.science/hal-05783324v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2725|SARS-CoV-2 detection and testing"
    ]
  ],
  "openalex": "W3163676327",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S2667038021000132/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-07",
  "publisher": "ScienceDirect",
  "ris": "https://research.draconitic.com/paper/4hs96mfyscx4c.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:50Z",
      "native_id": "hal-05783324",
      "source": "hal",
      "url": "https://hal.science/hal-05783324v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2725|SARS-CoV-2 detection and testing",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Interpretation of single target positivity among SARS-CoV-2 RT-PCR result tests",
  "title_text": "Interpretation of single target positivity among SARS-CoV-2 RT-PCR result tests",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:50Z",
  "url": "https://research.draconitic.com/paper/4hs96mfyscx4c",
  "venue": "Journal of Clinical Virology Plus",
  "versions": []
}