{
  "abstract": "Background: Follicular lymphoma (FL) is a common indolent non-Hodgkin lymphoma, reports of concurrent splenic infarction and pulmonary embolism as the initial complication are relatively uncommon. We report a case of high-grade follicular lymphoma presenting with pulmonary embolism and splenic infarction as prominent clinical features, aiming to improve the recognition of atypical manifestations of this disease.\n\nCase presentation: The patient was presented with long-term multiple enlarged lymph nodes throughout the body. Laboratory tests showed elevated D-dimer and β2-microglobulin levels, as well as thrombocytopenia. Imaging studies demonstrated multiple lymphadenopathies, marked splenomegaly with increased metabolic activity, and diffuse bone marrow hypermetabolism.\n\nResults: The patient underwent lymph node biopsy of the left cervical and right axillary regions, histopathological examination and immunohistochemistry of the lymph node biopsy confirmed the diagnosis of high-grade follicular lymphoma. Bone marrow examination revealed bone marrow infiltration. The patient received R-CDOP regimen chemotherapy, at the time of discharge, the patient’s condition was relatively stable.\n\nConclusion: This case suggests that in patients with unexplained splenomegaly complicated by thrombotic events and long-standing lymphadenopathy, a high index of suspicion for underlying follicular lymphoma or other lymphoproliferative disorders should be maintained. Standardized pathological and imaging evaluations are essential to guide precise treatment.",
  "abstract_shown": true,
  "affiliations": [
    "Department of General Medicine and Cardiopulmonary Rehabilitation, The Affiliated Hospital of Shaoxing University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Qijiang Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Chaoli Ding"
    },
    {
      "affs": [
        0
      ],
      "name": "Suping Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yumei Zeng"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4hwx4nreqrwvs.bib",
  "cited_by": 0,
  "doi": "10.3389/fonc.2026.1987312",
  "fulltext_url": null,
  "id": "4hwx4nreqrwvs",
  "issns": [
    "2234-943X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1987312/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-29",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/4hwx4nreqrwvs.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "10.3389/fonc.2026.1987312",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1987312/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:2234-943X",
      "subfield": "oncology"
    }
  ],
  "title": "Concurrent splenic infarction and pulmonary embolism as the initial presentation of high-grade follicular lymphoma: a case report",
  "title_text": "Concurrent splenic infarction and pulmonary embolism as the initial presentation of high-grade follicular lymphoma: a case report",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T00:21:08Z",
  "url": "https://research.draconitic.com/paper/4hwx4nreqrwvs",
  "venue": "Frontiers in Oncology",
  "versions": []
}