{
  "abstract": "Background: The influence of prior measles vaccination on humoral and cytokine immune responses during acute measles in adults remains insufficiently characterized. This study evaluated measles-specific IgM antibody levels, the early dynamics of interleukin (IL)-1β and IL-10, and their associations with hematological parameters according to documented vaccination status.\n\nMethods: This single-center observational study included 80 adults with clinically compatible measles and positive measles-specific IgM results who were hospitalized 3–5 days after disease onset with moderate or severe illness. Patients were classified as having documented prior measles vaccination (n = 40) or no documented evidence of prior measles vaccination (n = 40). Measles-specific IgM antibodies were measured by ELISA on day 7 after rash onset. Serum IL-1β, IL-10, total leukocyte count, and relative lymphocyte percentage were assessed at admission and on day 3 of hospitalization. Non-parametric statistical methods were applied for group comparisons and correlation analyses. An additional regression analysis was performed to assess between-group differences in IL-10 after adjustment for disease severity.\n\nResults: Patients with documented vaccination had significantly higher measles-specific IgM levels. IL-1β decreased and IL-10 increased significantly from admission to day 3 in both groups, with no between-group differences in IL-1β. In unadjusted analyses, IL-10 was higher in patients without documented vaccination at both time points. After adjustment for disease severity, the IL-10 difference at admission was no longer significant, whereas the difference on day 3 remained significant. Strong positive correlations between IL-1β and IL-10 were observed in both groups, while IgM correlated positively with relative lymphocyte percentage in patients without documented vaccination.\n\nConclusion: Documented prior measles vaccination was associated with higher measles-specific IgM levels, while the between-group difference in IL-10 on day 3 persisted after adjustment for disease severity. IL-1β dynamics were similar between the groups. These findings demonstrate differences in immune-response patterns between adults with documented prior measles vaccination and those without documented evidence of vaccination, while supporting cautious interpretation of these associations.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Infectious Diseases and Epidemiology, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine",
    "Municipal Non-Commercial Enterprise “Center for Infectious Diseases”, Ivano-Frankivsk, Ukraine",
    "Department of Internal Medicine No. 1, Clinical Immunology and Allergology Named After Academician E.M. Neiko, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine",
    "Interdepartmental Scientific Laboratory, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Olha Matviiuk",
      "orcid": "0000-0003-0186-8787"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Oleksandra Pryshliak"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Oleksandr Boichuk"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ihor Hryzhak"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Zoriana Tylishchak",
      "orcid": "0000-0002-7891-2849"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Taras Kobryn",
      "orcid": "0000-0003-4381-6045"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ruslan Miziuk",
      "orcid": "0000-0002-7829-9044"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Petro Gerych"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4j33925t1j8c0.bib",
  "cited_by": 0,
  "doi": "10.2147/idr.s641213",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696853/",
  "id": "4j33925t1j8c0",
  "issns": [
    "1178-6973"
  ],
  "landing_url": "https://doi.org/10.2147/idr.s641213",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2713|Virology and Viral Diseases"
    ]
  ],
  "openalex": "W7223000127",
  "pdf_url": "https://europepmc.org/articles/PMC13696853?pdf=render",
  "pmcid": "PMC13696853",
  "pmid": "42935665",
  "published": "2026-10-21",
  "publisher": "Dove Press",
  "ris": "https://research.draconitic.com/paper/4j33925t1j8c0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:08Z",
      "native_id": "PMC13696853",
      "source": "pmc",
      "url": "https://doi.org/10.2147/idr.s641213"
    },
    {
      "first_seen": "2026-10-30T12:22:12Z",
      "native_id": "MED:42935665",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42935665"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Virology and Viral Diseases",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Immunopathogenetic Features of Measles in Adults: Association of Vaccination Status with Measles-Specific IgM Levels and Cytokine Profile (IL-1β, IL-10)",
  "title_text": "Immunopathogenetic Features of Measles in Adults: Association of Vaccination Status with Measles-Specific IgM Levels and Cytokine Profile (IL-1β, IL-10)",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:34:07Z",
  "url": "https://research.draconitic.com/paper/4j33925t1j8c0",
  "venue": "Infection and Drug Resistance",
  "versions": []
}