{
  "abstract": "Acute myeloid leukemia (AML) is marked by unchecked expansion of undifferentiated myeloid cells. Although oncogenic fusions such as MLL-AF9 can initiate disease, the early steps of leukemogenesis and the role of cell-intrinsic regulators remain unclear. We previously showed that the Polycomb-associated factor Phf19 is required for hematopoietic stem cell (HSC) maintenance and state control in mice and that its loss (Phf19KO) impairs HSC function. To define Phf19's role in transformation, we expressed MLL-AF9 in Phf19KO hematopoietic cells and performed integrated multiomic analyses. Phf19 deletion promoted acquisition of stemlike features and reduced responsiveness to differentiation-inducing AML therapies. Molecular and functional consequences of Phf19 loss paralleled those observed in the datasets of patients with AML. From these data, we derived a prognostic signature-PHFScore-which reveals previously unrecognized AML survival-correlating genes that robustly stratify patients across distinct cellular origins and leukemogenic stages, underscoring Phf19's key role in AML biology and prognosis.",
  "abstract_shown": true,
  "affiliations": [
    "Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Carrer del Doctor Aiguader 88, Barcelona 08003, Spain.",
    "Universitat Ramon Llull, Blanquerna School of Health Science, Barcelona 08025, Spain.",
    "Centre Nacional d’Anàlisi Genòmica (CNAG), Baldiri I Reixac 4, Barcelona 08028, Spain.",
    "Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan 20139, Italy.",
    "Department of Oncology and Hematology-Oncology, University of Milan, Milan 20122, Italy.",
    "Universitat Pompeu Fabra (UPF), Barcelona, Spain.",
    "ICREA, Passeig Lluís Companys 23, Barcelona 08010, Spain."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Gianni Paolo Gamarra Figueroa"
    },
    {
      "affs": [
        0
      ],
      "name": "Arantxa Gutierrez",
      "orcid": "0000-0001-9033-3834"
    },
    {
      "affs": [
        0
      ],
      "name": "Enrique Blanco",
      "orcid": "0000-0001-6261-7370"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Pedro Vizán",
      "orcid": "0000-0002-6787-9940"
    },
    {
      "affs": [
        0
      ],
      "name": "Cecilia Ballaré",
      "orcid": "0000-0002-9442-807X"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Aleksandra Sparavier",
      "orcid": "0000-0002-1849-7268"
    },
    {
      "affs": [
        0
      ],
      "name": "Marta Tosto",
      "orcid": "0009-0002-6723-0647"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Saverio Minucci",
      "orcid": "0000-0001-5678-536X"
    },
    {
      "affs": [
        0,
        5
      ],
      "name": "Lars Velten",
      "orcid": "0000-0002-1233-5874"
    },
    {
      "affs": [
        0,
        5,
        6
      ],
      "name": "Luciano Di Croce",
      "orcid": "0000-0003-3488-6228"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4jamr9ztbkyw2.bib",
  "cited_by": 0,
  "doi": "10.1126/sciadv.aed6757",
  "fulltext_url": "https://europepmc.org/articles/PMC13693688",
  "id": "4jamr9ztbkyw2",
  "issns": [
    "2375-2548"
  ],
  "landing_url": "https://www.science.org/doi/10.1126/sciadv.aed6757",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2720|Acute Myeloid Leukemia Research"
    ]
  ],
  "openalex": "W7223288486",
  "pdf_url": "https://europepmc.org/articles/PMC13693688?pdf=render",
  "pmcid": "PMC13693688",
  "pmid": "42913019",
  "published": "2026-10-23",
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "ris": "https://research.draconitic.com/paper/4jamr9ztbkyw2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:41Z",
      "native_id": "10.1126/sciadv.aed6757",
      "source": "crossref",
      "url": "https://www.science.org/doi/10.1126/sciadv.aed6757"
    },
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42913019",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42913019"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2720|Acute Myeloid Leukemia Research",
      "subfield": "general"
    }
  ],
  "title": "Polycomb factor PHF19 affects AML initiation, patient prognosis, and survival",
  "title_text": "Polycomb factor PHF19 affects AML initiation, patient prognosis, and survival",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
  "url": "https://research.draconitic.com/paper/4jamr9ztbkyw2",
  "venue": "Science Advances",
  "versions": []
}