{
  "abstract": "HER2-positive breast cancer is well known for its aggressive nature and high incidence of central nervous system (CNS) metastasis, often affecting the brain parenchyma or leptomeninges. However, metastasis to the pituitary gland is exceedingly rare. We report a case of ER/PR-negative, HER2-positive breast cancer recurrence presenting with panhypopituitarism (PH) and central diabetes insipidus (CDI), resulting in hypernatremia-induced altered mental status. The patient had completed prior treatment with neoadjuvant chemotherapy, lumpectomy, and trastuzumab. Imaging revealed a temporal lobe mass with suprasellar enhancement. Surgical resection confirmed breast carcinoma metastasis. Hormonal studies confirmed PH and CDI. Management involved DDAVP, corticosteroids, fluid correction, whole-brain radiation, and systemic therapy with fam-trastuzumab deruxtecan-nxki (ENHERTU), leading to significant neurological recovery. This case highlights a rare metastatic pattern and the need for high clinical suspicion and multidisciplinary intervention.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Internal Medicine Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States",
    "Quinnipiac University - Frank H. Netter, MD School of Medicine, North Haven, Connecticut, United States",
    "Union College, Schenectady, New York, United States",
    "Department of Oncology St. Vincent’s Medical Center, Bridgeport, Connecticut, United States",
    "Department of Medicine Quinnipiac University - Frank H. Netter, MD School of Medicine - St. Vincent’s Medical Center, Bridgeport, Connecticut, United States",
    "Department of Oncology Quinnipiac University - Frank H. Netter, MD School of Medicine - St. Vincent’s Medical Center, Bridgeport, Connecticut, United States"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sushrut Ingawale"
    },
    {
      "affs": [
        1
      ],
      "name": "Yasheen Gao"
    },
    {
      "affs": [
        2
      ],
      "name": "Kirit Dhanjal"
    },
    {
      "affs": [
        3
      ],
      "name": "Barbara Addi"
    },
    {
      "affs": [
        4
      ],
      "name": "Kyung Ho Kim"
    },
    {
      "affs": [
        5
      ],
      "name": "Sandhya Dhanjal"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4jannf1w92779.bib",
  "cited_by": 0,
  "doi": "10.56305/001c.168604",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13730608/?tool=EBI",
  "id": "4jannf1w92779",
  "issns": [
    "2994-5593"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13730608",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Reports"
    ],
    [
      "openalex",
      "2712|Pituitary Gland Disorders and Treatments"
    ]
  ],
  "openalex": "W7225110668",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13730608/pdf/?tool=EBI",
  "pmcid": "PMC13730608",
  "pmid": "42979592",
  "published": "2026-10-01",
  "publisher": "Department of Medicine of Alpert Medical School of Brown University",
  "ris": "https://research.draconitic.com/paper/4jannf1w92779.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:46Z",
      "native_id": "PMC:PMC13730608",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13730608"
    },
    {
      "first_seen": "2026-11-07T12:23:07Z",
      "native_id": "PMC13730608",
      "source": "pmc",
      "url": "https://doi.org/10.56305/001c.168604"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2712|Pituitary Gland Disorders and Treatments",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "From Lethargy to Recovery: Central Diabetes Insipidus from Pituitary Metastasis in Recurrent HER2-Positive Breast Cancer Treated with Fam-Trastuzumab Deruxtecan-Nxki",
  "title_text": "From Lethargy to Recovery: Central Diabetes Insipidus from Pituitary Metastasis in Recurrent HER2-Positive Breast Cancer Treated with Fam-Trastuzumab Deruxtecan-Nxki",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:23:07Z",
  "url": "https://research.draconitic.com/paper/4jannf1w92779",
  "venue": "Journal of Brown hospital medicine",
  "versions": []
}