{
  "abstract": "Here, we present E3 Ligase Ligandalyzer Version 1.0, a freely accessible, recruiter-centric web platform for comparative exploration of experimentally resolved E3 ligase-recruiter complexes. The locked Version 1.0 dataset spans 35 E3 ligases, 604 reconciled recruiter entities, and 1,372 active structure-specific recruiter instances across 685 experimentally resolved PDB structures. Recruiters are linked to normalized chemical representations and analyzed using cheminformatics and structure-based workflows to compute physicochemical descriptors, scaffold relationships, aligned binding-pocket views, and solvent-accessible surface area patterns relevant to linker attachment. The platform integrates recruiter-entity, recruiter-instance, scaffold, and ligase views, allowing users to compare experimentally grounded chemical and structural observations without imposing predictive rankings. The platform supports direct transition into downstream degrader-design workflows, including integration with PROTAC Builder (protacbuilder.com). E3 Ligase Ligandalyzer is freely available at https://e3ligandalyzer.com, and the associated code and dataset-generation scripts are available at https://github.com/schurerlab/E3-Ligandalyzer-Scripts.",
  "abstract_shown": true,
  "affiliations": [
    "University of Miami Miller School of Medicine"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "J. M. Schulz"
    },
    {
      "name": "M. Bardhan"
    },
    {
      "name": "R. Reynolds"
    },
    {
      "name": "G. Leroy"
    },
    {
      "name": "D. Reinberg"
    },
    {
      "affs": [
        0
      ],
      "name": "S. C. M. Schurer"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4jqjbgv05qptj.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.07.757351",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.07.757351v1.full",
  "id": "4jqjbgv05qptj",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.07.757351v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "bioinformatics"
    ],
    [
      "openalex",
      "1312|Protein Degradation and Inhibitors"
    ]
  ],
  "openalex": "W7221804107",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.07.757351v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4jqjbgv05qptj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:27:52Z",
      "native_id": "10.64898/2026.10.07.757351",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.07.757351v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:bioinformatics",
      "subfield": "bioinformatics"
    }
  ],
  "title": "E3 Ligase Ligandalyzer: A Structure-First, Ligand-Centric Platform for E3 Ligase Recruiter Selection",
  "title_text": "E3 Ligase Ligandalyzer: A Structure-First, Ligand-Centric Platform for E3 Ligase Recruiter Selection",
  "type": "preprint",
  "updated_at": "2026-10-30T12:27:52Z",
  "url": "https://research.draconitic.com/paper/4jqjbgv05qptj",
  "venue": "bioRxiv",
  "versions": []
}