{
  "abstract": "Despite effective vaccines and antiviral therapies, patients with chronic hepatitis B (CHB) remain at risk of developing progressive liver fibrosis and cirrhosis. Vonafexor (VON), a second-generation synthetic non-steroidal, non-bile acid farnesoid X receptor agonist, has been shown to prevent liver fibrosis and target the HBV cccDNA reservoir. However, adherence to daily oral therapy is an established barrier to successful treatment of chronic infections. To overcome this barrier, VON was transformed into a long-acting (LA) prodrug nanosuspension. The LA prodrug formulation suppressed αSMA, TGFβ, and Col1A1 gene expression in the LX2 hepatic stellate cell line. The formulation was well tolerated and prevented liver and lung damage in a carbon tetrachloride-induced chronic liver injury model. The promising preclinical data support further development of LA VON prodrugs as potential treatments for liver and lung fibrosis.",
  "abstract_shown": true,
  "affiliations": [
    "Medical Sciences Interdepartmental Area Program, University of Nebraska Medical Center, Omaha, NE 68198, USA",
    "Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA",
    "Department of Environmental, Agricultural and Occupational Health, University of Nebraska Medical Center, Omaha, NE 68198, USA",
    "Department of Pathology, Microbiology and Immunology, and Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA",
    "Department of Internal Medicine, Pulmonary, Critical Care and Sleep Medicine Division, University of Nebraska Medical Center, Omaha, NE 68198, USA",
    "Veterans Affairs Nebraska-Western Iowa Health Care System, Research Service, 4101 Woolworth Avenue, Omaha, NE 68105, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ashrafi Sultana"
    },
    {
      "affs": [
        1
      ],
      "name": "Grace Bybee"
    },
    {
      "affs": [
        1
      ],
      "name": "Anup S. Pathania",
      "orcid": "0000-0002-1517-2919"
    },
    {
      "affs": [
        1
      ],
      "name": "Weimin Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Nam Thai Hoang Le",
      "orcid": "0009-0001-0492-1275"
    },
    {
      "affs": [
        1
      ],
      "name": "Brandon W. Hanson"
    },
    {
      "affs": [
        2
      ],
      "name": "Christopher D. Bauer"
    },
    {
      "affs": [
        2
      ],
      "name": "Deanna D. Mosley",
      "orcid": "0009-0006-8783-7576"
    },
    {
      "affs": [
        1
      ],
      "name": "Howard E. Gendelman",
      "orcid": "0000-0002-7831-0370"
    },
    {
      "affs": [
        3
      ],
      "name": "Samuel M. Cohen",
      "orcid": "0000-0002-5047-0962"
    },
    {
      "affs": [
        2,
        4,
        5
      ],
      "name": "Todd A. Wyatt",
      "orcid": "0000-0002-9273-6730"
    },
    {
      "affs": [
        1
      ],
      "name": "Larisa Y. Poluektova",
      "orcid": "0000-0001-7339-8732"
    },
    {
      "affs": [
        1
      ],
      "name": "Benson J. Edagwa",
      "orcid": "0000-0003-1484-9331"
    },
    {
      "affs": [
        1
      ],
      "name": "Natalia A. Osna",
      "orcid": "0000-0001-7498-0556"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4jz8p5qcf6mkg.bib",
  "cited_by": 0,
  "doi": "10.3390/biom16101443",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13702190/?tool=EBI",
  "id": "4jz8p5qcf6mkg",
  "issns": [
    "2218-273X"
  ],
  "landing_url": "https://www.mdpi.com/2218-273X/16/10/1443",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2721|Liver physiology and pathology"
    ]
  ],
  "openalex": "W7220443256",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13702190/pdf/?tool=EBI",
  "pmcid": "PMC13702190",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/4jz8p5qcf6mkg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:59Z",
      "native_id": "10.3390/biom16101443",
      "source": "crossref",
      "url": "https://www.mdpi.com/2218-273X/16/10/1443"
    },
    {
      "first_seen": "2026-10-30T12:21:48Z",
      "native_id": "PMC:PMC13702190",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13702190"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2721|Liver physiology and pathology",
      "subfield": "general"
    }
  ],
  "title": "A Long-Acting Farnesoid X Receptor (FXR) Agonist Prevents Fibrosis",
  "title_text": "A Long-Acting Farnesoid X Receptor (FXR) Agonist Prevents Fibrosis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:48Z",
  "url": "https://research.draconitic.com/paper/4jz8p5qcf6mkg",
  "venue": "Biomolecules",
  "versions": []
}