{
  "abstract": "Amyotrophic lateral sclerosis (ALS) has been suggested to be associated with a reduced incidence of pressure ulcers, although the underlying mechanisms remain unclear. Here, we investigated pressure ulcer formation using a cutaneous ischemia–reperfusion (I/R) injury model in SOD1-G93A mice, a model of familial ALS. Under steady-state conditions, oxidative stress was markedly elevated in the dorsal root ganglia (DRG) and spinal cord compared with skin, accompanied by reduced PGP9.5+ nerve fiber density in the skin. Following I/R injury, SOD1-G93A mice exhibited significantly attenuated ulcer formation during the early phase after reperfusion compared with wild-type mice. Quantitative PCR analysis demonstrated the reduced expression of oxidative stress-related genes, proinflammatory cytokines, and neuropeptides and their receptors in I/R skin site. Histological analyses revealed reduced infiltration of M1 macrophages, decreased 8-OHdG-positive oxidative DNA damage, and fewer apoptotic cells. Consistently, a denervation model showed reduced wound size after cutaneous I/R injury. Despite elevated oxidative stress in DRG and spinal cord, cutaneous oxidative and inflammatory responses were suppressed in SOD1-G93A mice. These findings suggest that impaired peripheral innervation attenuates neuropeptide-mediated inflammatory pathways, thereby reducing tissue injury following I/R and leading to decreased pressure ulcer formation in ALS.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Dermatology, Gunma University Graduate School of Medicine"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Akihiko Uchiyama"
    },
    {
      "affs": [
        0
      ],
      "name": "Akiko Sekiguchi"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuta Inoue"
    },
    {
      "affs": [
        0
      ],
      "name": "Shintaro Saito"
    },
    {
      "affs": [
        0
      ],
      "name": "Keiji Kosaka"
    },
    {
      "affs": [
        0
      ],
      "name": "Mayu Ohtaka"
    },
    {
      "affs": [
        0
      ],
      "name": "Takeshi Araki"
    },
    {
      "affs": [
        0
      ],
      "name": "Takayuki Shuto"
    },
    {
      "affs": [
        0
      ],
      "name": "Azusa Ida"
    },
    {
      "affs": [
        0
      ],
      "name": "Yoko Yokoyama"
    },
    {
      "affs": [
        0
      ],
      "name": "Sachiko Ogino"
    },
    {
      "affs": [
        0
      ],
      "name": "Ryoko Torii"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuki Watanuki"
    },
    {
      "affs": [
        0
      ],
      "name": "Sei-ichiro Motegi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4k77n2sx1y4cx.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-63449-4",
  "fulltext_url": "https://doi.org/10.1038/s41598-026-63449-4",
  "id": "4k77n2sx1y4cx",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://doi.org/10.1038/s41598-026-63449-4",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "Q"
    ],
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "3609|Pressure Ulcer Prevention and Management"
    ]
  ],
  "openalex": "W7170049376",
  "pdf_url": "https://www.nature.com/articles/s41598-026-63449-4_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-01",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/4k77n2sx1y4cx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:57Z",
      "native_id": "7f1cd2c161af4ee4bacb2259ce64c3e9",
      "source": "doaj",
      "url": "https://doi.org/10.1038/s41598-026-63449-4"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:R",
      "subfield": "general"
    }
  ],
  "title": "Reduced neuropeptide signaling attenuates ischemia–reperfusion–induced pressure ulcer formation in SOD1-G93A mice",
  "title_text": "Reduced neuropeptide signaling attenuates ischemia–reperfusion–induced pressure ulcer formation in SOD1-G93A mice",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:57Z",
  "url": "https://research.draconitic.com/paper/4k77n2sx1y4cx",
  "venue": "Scientific Reports",
  "versions": []
}