{
  "abstract": "Importance\n\nGiven the high prevalence, chronicity, and associated disability of obsessive-compulsive disorder (OCD), optimizing treatment is a global priority. The Bergen 4-day treatment (B4DT), a concentrated exposure-based intervention, may reduce treatment burden and improve access to evidence-based care.Objective\n\nTo evaluate the efficacy of B4DT compared with internet-based cognitive behavioral therapy (iCBT) in reducing OCD symptom severity.Design, setting, and participants\n\nSingle-center randomized controlled trial (1:1 allocation). Between May 8, 2024, and August 8, 2025, adults (aged 18 to 72 years) with OCD were enrolled and were followed up for 3 months. Key exclusion criteria included schizophrenia, bipolar disorder, acute suicidality, substance dependence, and recent psychopharmacological changes. Outcomes were assessed at baseline, 6 weeks, 8 weeks (posttreatment), and 3 months (follow-up) by masked evaluators.Interventions\n\nPatients were randomized to B4DT (including preparatory sessions) or an 8-week unguided iCBT program.Main outcomes and measures\n\nThe primary outcome was the change in OCD symptom severity, measured by the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Secondary outcomes included self-reported OCD (OCI-R), dysfunctional cognitions, quality of life, depressive symptoms, experiential avoidance, global functioning, self-esteem, and treatment satisfaction.Results\n\nA total of 253 individuals were screened, and 119 were enrolled after 53 were found to be ineligible and 81 declined to participate. Sixty of the 119 randomized participants (mean [SD] age, 33.5 [10.1] years; 79 [66.4%] women) were assigned to B4DT and 59 to iCBT. The primary analysis included all randomized participants (intention-to-treat). B4DT was associated with significantly greater reductions in OCD symptoms (Y-BOCS) than iCBT, with large effects at posttreatment (mean [SE] difference, -7.9 [0.9]; 95% CI, -9.7 to -6.0; Hedges g, -1.6) and sustained effects at 3-month follow-up (mean [SE] difference, -5.6 [1.1]; 95% CI, -7.8 to -3.4; Hedges g, -1.0). Secondary outcomes consistently favored B4DT. Response and remission rates at 3-month follow-up were higher with B4DT (35 of 57 [61.4%] vs 11 of 44 [25.0%] and 24 of 57 [42.1%] vs 6 of 44 [13.6%], respectively).Conclusions and relevance\n\nIn this randomized clinical trial of 119 adults with OCD, B4DT was superior to iCBT in reducing OCD symptom severity, with sustained benefits. Its brief, concentrated format may represent a scalable strategy to improve access to effective OCD treatment globally.Trial registration\n\nGerman Clinical Trials Register: DRKS00034236.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.",
    "Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Lena Jelinek"
    },
    {
      "affs": [
        0
      ],
      "name": "Lara Wille"
    },
    {
      "affs": [
        0
      ],
      "name": "Jakob Scheunemann"
    },
    {
      "affs": [
        0
      ],
      "name": "Luisa Tegtmeier"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Holger Zapf"
    },
    {
      "affs": [
        0
      ],
      "name": "Franziska Miegel"
    },
    {
      "affs": [
        0
      ],
      "name": "Lea Schuurmans"
    },
    {
      "affs": [
        0
      ],
      "name": "Josephine Schultz"
    },
    {
      "affs": [
        0
      ],
      "name": "Jürgen Gallinat"
    },
    {
      "affs": [
        0
      ],
      "name": "Amir H Yassari"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4k8t5jr0aejwk.bib",
  "cited_by": 0,
  "doi": "10.1001/jamanetworkopen.2026.39281",
  "fulltext_url": "https://europepmc.org/articles/PMC13681233",
  "id": "4k8t5jr0aejwk",
  "issns": [
    "2574-3805"
  ],
  "landing_url": "https://europepmc.org/article/MED/42895747",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "3203|Obsessive-Compulsive Spectrum Disorders"
    ]
  ],
  "openalex": "W7222921557",
  "pdf_url": "https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2855476/jelinek_2026_oi_261062_1791821843.7857.pdf",
  "pmcid": "PMC13681233",
  "pmid": "42895747",
  "published": "2026-10-01",
  "publisher": "American Medical Association (AMA)",
  "ris": "https://research.draconitic.com/paper/4k8t5jr0aejwk.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:37Z",
      "native_id": "MED:42895747",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42895747"
    },
    {
      "first_seen": "2026-10-30T12:19:46Z",
      "native_id": "10.1001/jamanetworkopen.2026.39281",
      "source": "crossref",
      "url": "https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2855476"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3203|Obsessive-Compulsive Spectrum Disorders",
      "subfield": "psychiatry"
    }
  ],
  "title": "Concentrated Exposure Therapy vs Internet-Based Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder: A Randomized Clinical Trial.",
  "title_text": "Concentrated Exposure Therapy vs Internet-Based Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder: A Randomized Clinical Trial.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:46Z",
  "url": "https://research.draconitic.com/paper/4k8t5jr0aejwk",
  "venue": "JAMA network open",
  "versions": []
}