{
  "abstract": "Objective\n\nTo systematically evaluate the effect of pre-membrane blood acidification, compared with conventional extracorporeal carbon dioxide removal without acidification, on extracorporeal - carbon dioxide elimination in large animal models undergoing mechanical ventilation.Methods\n\nThis protocol is prospectively registered in PROSPERO and will be conducted in accordance with PRISMA-P guidelines. We will include preclinical experimental studies in large animals (e.g., swine, sheep, goats, cattle, or dogs) evaluating pre-membrane acidification associated with extracorporeal carbon dioxide removal. We will conduct electronic searches in PubMed®, Web of Science, Scopus, Embase, and Google Scholar from database inception to December 2025, without language restrictions. Two independent reviewers will conduct study selection, data extraction, and risk-of-bias assessment using the SYRCLE tool. The primary outcome will be extracorporeal carbon dioxide elimination. When appropriate, we will conduct meta-analyses using random-effects models. We will standardize carbon dioxide elimination values by body weight (mL/kg/minute) to improve comparability across species.Results\n\nThis review will provide a structured synthesis of preclinical evidence regarding the magnitude and consistency of the effect of pre-membrane acidification on carbon dioxide elimination, ventilatory parameters, and adverse events.Conclusion\n\nBy systematically evaluating available experimental data, this review aims to clarify the potential role of pre-membrane acidification as an adjunctive strategy to extracorporeal carbon dioxide removal and to identify knowledge gaps relevant for future translational and clinical research.",
  "abstract_shown": true,
  "affiliations": [
    "Faculdade de Medicina, Universidade de São Paulo - São Paulo (SP), Brazil.",
    "Intensive Care Unit, Hospital Sírio-Libanês - São Paulo (SP), Brazil.",
    "Medical Intensive Care Unit, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo - São Paulo (SP), Brazil.",
    "Pulmonary Division, Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo - São Paulo (SP), Brazil."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Vagner Pires de Campos Júnior",
      "orcid": "0000-0001-8279-6302"
    },
    {
      "affs": [
        0
      ],
      "name": "Anne Caroline de Almeida Sousa",
      "orcid": "0000-0001-8788-7641"
    },
    {
      "affs": [
        1
      ],
      "name": "Yuri de Albuquerque Pessoa Dos Santos",
      "orcid": "0000-0003-4169-6078"
    },
    {
      "affs": [
        2
      ],
      "name": "Maristela Carvalho"
    },
    {
      "affs": [
        3
      ],
      "name": "Marcelo Amato Britto Passos",
      "orcid": "0000-0003-3525-8282"
    },
    {
      "affs": [
        3
      ],
      "name": "Eduardo Leite Vieira Costa",
      "orcid": "0000-0002-6941-3626"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4ks2221b24325.bib",
  "cited_by": 0,
  "doi": "10.62675/2965-2774.20260105",
  "fulltext_url": "https://europepmc.org/articles/PMC13690042",
  "id": "4ks2221b24325",
  "issns": [
    "2965-2774"
  ],
  "landing_url": "https://europepmc.org/article/MED/42961286",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2204|Mechanical Circulatory Support Devices"
    ]
  ],
  "openalex": "W7214753926",
  "pdf_url": "https://europepmc.org/articles/PMC13690042?pdf=render",
  "pmcid": "PMC13690042",
  "pmid": "42961286",
  "published": "2026-10-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4ks2221b24325.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:50Z",
      "native_id": "MED:42961286",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42961286"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Effects of pre-membrane acidification on extracorporeal CO2 removal compared with conventional ECCO2R in mechanically ventilated animal models: a preclinical systematic review protocol.",
  "title_text": "Effects of pre-membrane acidification on extracorporeal CO2 removal compared with conventional ECCO2R in mechanically ventilated animal models: a preclinical systematic review protocol.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T03:21:21Z",
  "url": "https://research.draconitic.com/paper/4ks2221b24325",
  "venue": "Critical care science",
  "versions": []
}