{
  "abstract": "Objective: To investigate the clinical efficacy, safety and prognostic influencing factors of carbon ion radiotherapy (CIRT) in patients with limited-stage small-cell lung cancer (LS-SCLC).\n\nMethods: The clinical data of 39 patients with LS-SCLC who received CIRT from June 2020 to August 2026 were retrospectively analyzed. Survival outcomes and adverse reactions were evaluated, and Cox regression was used to analyze prognostic factors.\n\nResults: All patients completed the treatment. The 3-month objective response rate (ORR) was 64.10%. The 1- and 2-year local control rates were both 91.2%. The 1- and 2-year overall survival (OS) rates were 91.65% and 62.45%, with a median OS of 44 months. The 1- and 2-year progression-free survival (PFS) rates were 72.00% and 47.77%, with a median PFS of 24 months. Serum levels of NSE, CYFRA21-1, SCC and CEA decreased significantly after treatment. Acute treatment-related adverse reactions were mainly grade I-II and could be relieved after symptomatic treatment. Stratified Cox regression indicated that KPS score was an independent protective factor for OS. Univariate analysis suggested that the magnitude of post-treatment reduction in SCC and CYFRA21-1 was potentially associated with survival outcomes.\n\nConclusion: CIRT achieves favorable local tumor control with low acute radiotherapy-related toxicity, and can serve as an alternative therapeutic option for LS-SCLC. This is a single-center, small-sample retrospective study, and the conclusions regarding efficacy and prognosis need to be further verified in larger-sample cohorts.",
  "abstract_shown": true,
  "affiliations": [
    "School of Public Health, Gansu University of Chinese Medicine , , ,",
    "Department I, Radiation Therapy Center, Gansu Wuwei Tumour Hospital , , ,",
    "Follow-up Office, Gansu Wuwei Tumour Hospital , , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xuexue Liang"
    },
    {
      "affs": [
        0
      ],
      "name": "Qinli Gong"
    },
    {
      "affs": [
        1
      ],
      "name": "Yihe Zhang"
    },
    {
      "affs": [
        2
      ],
      "name": "Ling Tian"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaoli Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Bole Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhenglin Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Pengqing Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Yancheng Ye"
    },
    {
      "affs": [
        2
      ],
      "name": "Yanshan Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4ksaan4ekrt79.bib",
  "cited_by": 0,
  "doi": "10.3389/fonc.2026.1898779",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13668746/?tool=EBI",
  "id": "4ksaan4ekrt79",
  "issns": [
    "2234-943X"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13668746",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Lung Cancer Research Studies"
    ]
  ],
  "openalex": "W7215122437",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13668746/pdf/?tool=EBI",
  "pmcid": "PMC13668746",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/4ksaan4ekrt79.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:25Z",
      "native_id": "PMC:PMC13668746",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13668746"
    },
    {
      "first_seen": "2026-10-30T12:20:13Z",
      "native_id": "10.3389/fonc.2026.1898779",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1898779/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Lung Cancer Research Studies",
      "subfield": "oncology"
    }
  ],
  "title": "Survival and prognostic factors analysis of carbon ion radiotherapy for limited-stage small cell lung cancer",
  "title_text": "Survival and prognostic factors analysis of carbon ion radiotherapy for limited-stage small cell lung cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:13Z",
  "url": "https://research.draconitic.com/paper/4ksaan4ekrt79",
  "venue": "Frontiers in oncology",
  "versions": []
}