{
  "abstract": "To examine the safety and feasibility of a two-week (seven-session) tele-based ischemic conditioning (tele-IC) intervention in individuals with chronic stroke and to explore secondary neurophysiological and motor outcomes. Methods: Ten individuals with chronic stroke (8 males; age 61.7 ± 7.3 years; time since stroke 11.5 ± 7.5 years; Fugl-Meyer Lower Extremity score 20.5 ± 6.6) completed tele-IC. The primary outcomes were safety and feasibility. Safety was assessed through monitoring of IC-related adverse events and side effects across sessions; feasibility was evaluated through screening-to-enrollment, retention, intervention adherence, tolerability, and acceptability. Secondary exploratory outcomes included corticomotor excitability, transcallosal inhibition, lower-limb strength, paretic ankle motor control, and gait speed. Outcomes were assessed before and 24 h after the intervention. Results: Across 70 tele-IC sessions, no serious adverse events occurred, and all 10 participants completed all seven sessions. Acceptability was high, including ratings for safety (4.9/5), remote assistance (4.8/5), and overall satisfaction (4.8/5). Exploratory analyses showed increased transcallosal inhibition (d_z = 0.929, p = 0.017), changes in bilateral lower-limb strength (d_z = 0.873–1.756), and shorter paretic ankle reaction time (d_z = 0.844, p = 0.049). Corticomotor excitability and gait speed did not significantly change. Conclusions: In this small, uncontrolled pilot study, synchronously supervised tele-IC was delivered with complete intervention adherence, no serious adverse events, and high participant acceptability. Exploratory secondary neurophysiological and motor findings require confirmation in larger controlled trials.",
  "abstract_shown": true,
  "affiliations": [
    "Corresponding author at: Department of Physical Therapy, University of Illinois Chicago",
    "Brain Plasticity Laboratory, Department of Physical Therapy, University of Illinois Chicago, Chicago, IL, USA"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sangeetha Madhavan"
    },
    {
      "affs": [
        1
      ],
      "name": "Mark Cummings"
    },
    {
      "affs": [
        1
      ],
      "name": "Danny Mathew"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4ksvyzq1egggk.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jstrokecerebrovasdis.2026.108772",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S1052305726002351",
  "id": "4ksvyzq1egggk",
  "issns": [
    "1532-8511"
  ],
  "landing_url": "https://doi.org/10.1016/j.jstrokecerebrovasdis.2026.108772",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC346-429"
    ],
    [
      "openalex",
      "2742|Stroke Rehabilitation and Recovery"
    ]
  ],
  "openalex": "W7223012385",
  "pdf_url": "https://www.strokejournal.org/article/S1052-3057(26)00235-1/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-30",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/4ksvyzq1egggk.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:57Z",
      "native_id": "9b6cd111d1464916a0ea41bb5cf4eb09",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.jstrokecerebrovasdis.2026.108772"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RC346-429",
      "subfield": "neurology"
    }
  ],
  "title": "Tele-based ischemic conditioning for chronic stroke: Safety, feasibility, and preliminary neurophysiological and motor effects",
  "title_text": "Tele-based ischemic conditioning for chronic stroke: Safety, feasibility, and preliminary neurophysiological and motor effects",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:57Z",
  "url": "https://research.draconitic.com/paper/4ksvyzq1egggk",
  "venue": "Journal of Stroke and Cerebrovascular Diseases",
  "versions": []
}