{
  "abstract": "Adolescent and early-onset adenomyosis is increasingly recognized in symptomatic young patients, but its clinical significance remains uncertain. This narrative review synthesizes English-language literature on adolescent and early-onset adenomyosis, distinguishing direct adolescent and young-adult evidence from supportive evidence derived from adult populations. Current data suggest that adenomyosis-like imaging features may be identified in adolescents with severe dysmenorrhea, heavy menstrual bleeding, chronic pelvic pain, or coexisting endometriosis. Early disease often appears as subtle diffuse inner-myometrial change, focal lesions, or cystic/juvenile forms rather than the classic diffuse adult phenotype. Ultrasound is the first-line imaging modality, whereas MRI is reserved for equivocal findings, atypical cystic lesions, suspected congenital anomalies, or endometriosis overlap. Management requires a stepwise, symptom-oriented approach that considers future reproductive options and avoids unnecessary uterine intervention. Overall, adolescent adenomyosis should be considered in patients with severe or treatment-resistant menstrual symptoms, while uncertain imaging findings should not be overinterpreted.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.",
    "National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, Hubei, 430030, China.",
    "Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, Wuhan, Hubei, 430030, China."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Shuhong Yang"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yuling Chen"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Xiangyi Ma"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4m0w3v6y1mt7z.bib",
  "cited_by": 0,
  "doi": "10.7150/ijms.140803",
  "fulltext_url": "https://europepmc.org/articles/PMC13685038",
  "id": "4m0w3v6y1mt7z",
  "issns": [
    "1449-1907"
  ],
  "landing_url": "https://europepmc.org/article/MED/42910152",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2743|Endometriosis Research and Treatment"
    ]
  ],
  "openalex": "W7222872943",
  "pdf_url": "https://europepmc.org/articles/PMC13685038?pdf=render",
  "pmcid": "PMC13685038",
  "pmid": "42910152",
  "published": "2026-10-02",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4m0w3v6y1mt7z.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "MED:42910152",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42910152"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2743|Endometriosis Research and Treatment",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Adolescent and Early-Onset Adenomyosis: Phenotypes, Diagnostic Challenges, and Fertility-Conscious Care.",
  "title_text": "Adolescent and Early-Onset Adenomyosis: Phenotypes, Diagnostic Challenges, and Fertility-Conscious Care.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:14Z",
  "url": "https://research.draconitic.com/paper/4m0w3v6y1mt7z",
  "venue": "International journal of medical sciences",
  "versions": []
}