{
  "abstract": "Non-small cell lung cancer (NSCLC), the leading contributor to global cancer mortality, is associated with a notably unfavorable prognosis. This study aims to explore the regulatory interaction between A1BG-AS1 and miR-3942-5p and its molecular mechanisms. The level of A1BG-AS1 and miR-3942-5p in both tumor tissues and cell lines (BEAS-2B, A549, H226) were measured using qPCR. Functional effects of A1BG-AS1 overexpression in NSCLC cells were evaluated through CCK-8, flow cytometry, and Transwell assays. The interaction between A1BG-AS1 and miR-3942-5p was validated through dual-luciferase reporter assays and rescue studies. A1BG-AS1 expression was markedly reduced in both NSCLC tissues and cell lines. A1BG-AS1 expression was significantly associated with various clinical parameters. Overexpression of A1BG-AS1 suppressed NSCLC cell function. Mechanistically, A1BG-AS1 interacted with and negatively regulated miR-3942-5p, and the antitumor effects of A1BG-AS1 overexpression were reversed by miR-3942-5p mimics.A1BG-AS1 inhibits NSCLC tumor progression by targeting miR-3942-5p.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Thoracic Surgery, Linyi People's Hospital, Linyi, China.",
    "Internal Medicine Department, Ward 1, Linyi Cancer Hospital, Linyi, China.",
    "Department of Surgery, Yinan County ShuangHou Town Health Center, Linyi, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jiahui Du"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhenhua Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Chunqiang Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xuexi Zhang",
      "orcid": "0009-0004-7130-9651"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4m1t2qjja84xw.bib",
  "cited_by": 0,
  "doi": "10.1002/jbt.71151",
  "fulltext_url": "https://europepmc.org/articles/PMC13717211",
  "id": "4m1t2qjja84xw",
  "issns": [
    "1095-6670",
    "1099-0461"
  ],
  "landing_url": "https://europepmc.org/article/MED/42952240",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "1306|Cancer-related molecular mechanisms research"
    ]
  ],
  "openalex": "W7224270279",
  "pdf_url": "https://europepmc.org/articles/PMC13717211?pdf=render",
  "pmcid": "PMC13717211",
  "pmid": "42952240",
  "published": "2026-10-28",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4m1t2qjja84xw.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:33Z",
      "native_id": "MED:42952240",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42952240"
    },
    {
      "first_seen": "2026-11-02T12:21:34Z",
      "native_id": "PMC13717211",
      "source": "pmc",
      "url": "https://doi.org/10.1002/jbt.71151"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|Cancer-related molecular mechanisms research",
      "subfield": "oncology"
    }
  ],
  "title": "LncRNA A1BGAS1 Serves as a Tumor Suppressor in Non-Small Cell Lung Cancer by Modulating the Expression of miR-3942-5P.",
  "title_text": "LncRNA A1BGAS1 Serves as a Tumor Suppressor in Non-Small Cell Lung Cancer by Modulating the Expression of miR-3942-5P.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:21:34Z",
  "url": "https://research.draconitic.com/paper/4m1t2qjja84xw",
  "venue": "Journal of biochemical and molecular toxicology",
  "versions": []
}