{
  "abstract": "Polyglutamine (polyQ) diseases are fatal neurodegenerative disorders caused by pathological cytosine-adenine-guanine (CAG) repeat expansions in disease-associated genes. They are characterized by progressive motor dysfunction and typically late onset. Although multiple mechanisms have been proposed, accumulating evidence indicates that lipid dysregulation contributes to neuronal dysfunction and degeneration. Lipids are essential for brain development and homeostasis, and disrupted lipid metabolism is implicated across neurodegenerative conditions. Within the polyQ spectrum, Huntington’s disease is the best studied and shows strong links between altered lipid pathways and neuronal pathology, whereas the role of lipid dysregulation in other polyQ disorders remains less well defined. In this review, we summarize key lipid functions in the central nervous system, synthesize reported lipid alterations across polyQ diseases, and evaluate the therapeutic potential of targeting lipid metabolism.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA",
    "Department of Molecular, Cellular, and Developmental Biology, Yale College, New Haven, CT, 06510, USA",
    "Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA",
    "Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale School of Medicine, New Haven, CT 06510, USA",
    "Ludwig Program for the Study of Neuroimmune Interactions in Dementia, Yale School of Medicine, New Haven, CT 06510, USA",
    "Wu Tsai Institute, Yale School of Medicine, New Haven, CT 06510, USA"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Luhan Ni"
    },
    {
      "affs": [
        0
      ],
      "name": "Vaishnavi Veeranki"
    },
    {
      "affs": [
        1
      ],
      "name": "Byron Huang"
    },
    {
      "affs": [
        0,
        2,
        3,
        4,
        5
      ],
      "name": "Janghoo Lim"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4m5hepfqqk088.bib",
  "cited_by": 0,
  "doi": "10.1016/j.mocell.2026.100406",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13742215/",
  "id": "4m5hepfqqk088",
  "issns": [
    "1016-8478",
    "0219-1032"
  ],
  "landing_url": "https://doi.org/10.1016/j.mocell.2026.100406",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review Article"
    ],
    [
      "openalex",
      "2804|Genetic Neurodegenerative Diseases"
    ]
  ],
  "openalex": "W7221749722",
  "pdf_url": null,
  "pmcid": "PMC13742215",
  "pmid": "42874745",
  "published": "2026-10-14",
  "publisher": "Korean Society for Molecular and Cellular Biology",
  "ris": "https://research.draconitic.com/paper/4m5hepfqqk088.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T12:23:05Z",
      "native_id": "PMC13742215",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.mocell.2026.100406"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2804|Genetic Neurodegenerative Diseases",
      "subfield": "neuroscience"
    }
  ],
  "title": "Lipid dysregulation in polyglutamine diseases",
  "title_text": "Lipid dysregulation in polyglutamine diseases",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T12:23:05Z",
  "url": "https://research.draconitic.com/paper/4m5hepfqqk088",
  "venue": "Molecules and Cells",
  "versions": []
}