{
  "abstract": "Immunogenic cell death (ICD) provides a promising strategy for cancer treatment by stimulating anti-tumor immunity. However, single ICD inducers often elicit insufficient damage-associated molecular patterns (DAMPs), and the rapid clearance of these DAMPs at the tumor site further prevents sustained immune stimulation. To address these challenges, we developed a polyphenol-based bioadhesive hydrogel antigen reservoir functionalized with dopamine (DA) and loaded with dual ICD inducers. Specifically, thymidine kinase (tk)-deficient oncolytic vaccinia virus (VV, a type II ICD inducer) was combined with oxaliplatin (OXA, a type I ICD inducer), thereby enhancing direct tumor cytotoxicity and synergistically amplifying ICD through distinct mechanisms to promote robust DAMP release. Subsequently, the released DAMPs were captured and retained by the DA-functionalized hyaluronic acid-Pluronic® F127 hydrogel (HADP), forming an antigen reservoir at the tumor site. This synergistic \"stimulate-and-retain\" strategy not only augments ICD-mediated DAMP release but also prolongs their local availability to sustain immune stimulation. In murine models, the OXA-HADP@VV facilitated dendritic cell (DC) activation, increased IFN-γ ⁺CD8⁺ T cell infiltration, and reduced regulatory T cells (Tregs), thereby achieving effective tumor suppression and strong anti-recurrence effects. Together, this dual ICD-inducing antigen reservoir provides a versatile platform for improving cancer immunotherapy.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China.",
    "School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China.",
    "Department of Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Dan Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Anxian Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Haimeng Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenjing Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Qili Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Hongzhong Chen"
    },
    {
      "affs": [
        2
      ],
      "name": "Jiaxing Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Li Yang"
    },
    {
      "affs": [
        1
      ],
      "name": "Caijun Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaowei Zeng"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4mbk5a2pvmvwp.bib",
  "cited_by": 0,
  "doi": "10.1016/j.apsb.2026.07.040",
  "fulltext_url": "https://europepmc.org/articles/PMC13712287",
  "id": "4mbk5a2pvmvwp",
  "issns": [
    "2211-3835",
    "2211-3843"
  ],
  "landing_url": "https://europepmc.org/article/MED/42948701",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2403|Immunotherapy and Immune Responses"
    ]
  ],
  "openalex": "W7171672771",
  "pdf_url": "https://europepmc.org/articles/PMC13712287?pdf=render",
  "pmcid": "PMC13712287",
  "pmid": "42948701",
  "published": "2026-07-29",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/4mbk5a2pvmvwp.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:36Z",
      "native_id": "MED:42948701",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42948701"
    },
    {
      "first_seen": "2026-10-31T12:22:54Z",
      "native_id": "PMC13712287",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.apsb.2026.07.040"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Immunotherapy and Immune Responses",
      "subfield": "immunology"
    }
  ],
  "title": "Stimulate-and-retain hydrogel strategy integrating oncolytic virus and oxaliplatin for dual ICD-inducing antitumor immunity.",
  "title_text": "Stimulate-and-retain hydrogel strategy integrating oncolytic virus and oxaliplatin for dual ICD-inducing antitumor immunity.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:22:54Z",
  "url": "https://research.draconitic.com/paper/4mbk5a2pvmvwp",
  "venue": "Acta pharmaceutica Sinica. B",
  "versions": []
}