{
  "abstract": "Hydraulic engineering-driven thermal lag disturbs natural water temperature and induces thermal stress in early-life-stage Chinese sturgeon (Acipenser sinensis), yet stage-specific molecular stress mechanisms remain unclear. This study assessed phenotypic, proteomic and metabolomic responses of endogenous-nutrition embryos and exogenous first-feeding larvae under 16 °C, 19 °C and 22 °C. Phenotypic results showed optimal embryo survival at 16 °C (hatching rate 64.6%), maximum larval growth at 19 °C (specific growth rate 6.79%/d), and severe developmental suppression at 22 °C (with the hatching rate dropping by 49.6 percentage points relative to 16 °C). Multi-omics uncovered distinct injury pathways: high temperature disrupted amino-acid and fatty-acid catabolism and triggered organic-acid accumulation and energy deficiency in embryos; in first-feeding larvae, it activated ferroptosis, polyunsaturated fatty-acid peroxidation and lysosomal pathways to produce oxidative damage. These findings demonstrate that a 1-3 °C temperature rise exceeds stage-specific thermal tolerance, with embryos succumbing to \"metabolic suppression-energy deficiency\" and larvae to \"oxidative stress-ferroptosis\". This study provides the first integrative proteomic and metabolomic evidence of stage-dependent thermal injury mechanisms in sturgeon, offering mechanistic insights critical for conservation physiology and informing conservation actions for this endangered sturgeon species.",
  "abstract_shown": true,
  "affiliations": [
    "Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China.",
    "College of Fisheries and Life Science, Shanghai Ocean University, Shanghai 201306, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xiaoqian Leng"
    },
    {
      "affs": [
        0
      ],
      "name": "Junlin Yang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Xinchi Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiong Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Ke Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiang Luo"
    },
    {
      "affs": [
        0
      ],
      "name": "Wei Xiong"
    },
    {
      "affs": [
        0
      ],
      "name": "Jinping Wu",
      "orcid": "0000-0002-3416-7322"
    },
    {
      "affs": [
        0
      ],
      "name": "Luoxin Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuan Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jinming Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Junyi Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4mgjde57gbzcm.bib",
  "cited_by": 0,
  "doi": "10.3390/biology15191713",
  "fulltext_url": "https://europepmc.org/articles/PMC13663467",
  "id": "4mgjde57gbzcm",
  "issns": [
    "2079-7737"
  ],
  "landing_url": "https://europepmc.org/article/MED/42883386",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2303|Physiological and biochemical adaptations"
    ]
  ],
  "openalex": "W7214606385",
  "pdf_url": "https://europepmc.org/articles/PMC13663467?pdf=render",
  "pmcid": "PMC13663467",
  "pmid": "42883386",
  "published": "2026-09-26",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4mgjde57gbzcm.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42883386",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42883386"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2303|Physiological and biochemical adaptations",
      "subfield": "ecology"
    }
  ],
  "title": "Stage-Dependent Heat-Stress Mechanisms in Chinese Sturgeon (Acipenser sinensis) Early Life-Stages Under Simulated Thermal-Lag Effect.",
  "title_text": "Stage-Dependent Heat-Stress Mechanisms in Chinese Sturgeon (Acipenser sinensis) Early Life-Stages Under Simulated Thermal-Lag Effect.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/4mgjde57gbzcm",
  "venue": "Biology",
  "versions": []
}