{
  "abstract": "Human parvovirus B19 (B19V) usually causes self-limiting infection but can cause severe complications in pregnancy, chronic hemolytic disease, and immunocompromise. Contemporary data on B19V immunity in Southeast Asia remain limited. We conducted an age-stratified, cross-sectional serosurvey of 430 residual specimens from four Thai provinces (April to August 2024) and compared findings against published age-specific data from 13 countries. Anti-B19V IgG was measured by quantitative ELISA, with seropositivity defined as 5.5 IU/mL or higher. Overall, 87 of 430 participants (20.2%; 95% CI, 16.5 to 24.3%) were seropositive, with a non-monotonic age pattern: 31.7% among children aged 0 to 5, falling to 4.7% at 6 to 12 years, then rising to 51.2% among those 60 and older. A serocatalytic model estimated an average constant force of infection of 8.5 per 1000 person-years beyond age 6; the present data did not provide evidence for the concentrated school-age transmission peak reported in Japan and Europe. From school age onward, Thai seroprevalence was toward the lower end of published estimates, a pattern shared with other Southeast and East Asian settings, although differences in assays, sampling frames, and study periods limit direct comparison. Seroprevalence was similarly elevated among children aged 1 to 2 and 3 to 5 years, and was therefore not concentrated in infancy; most seropositive young children had IgG concentrations close to the assay cut-off, and the explanation for this pattern remains uncertain. No significant differences by sex or province were observed. These findings suggest that a substantial proportion of adolescents and adults in the populations sampled lack detectable anti-B19V IgG and may remain susceptible to infection.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pediatrics, Center of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.",
    "The Royal Society of Thailand, Sanam Sueapa, Bangkok 10300, Thailand."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Pornjarim Nilyanimit",
      "orcid": "0000-0003-2250-0017"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiratchaya Puenpa"
    },
    {
      "affs": [
        0
      ],
      "name": "Nungruthai Suntronwong"
    },
    {
      "affs": [
        0
      ],
      "name": "Sirapa Klinfueng"
    },
    {
      "affs": [
        0
      ],
      "name": "Ritthideach Yorsaeng",
      "orcid": "0000-0001-9391-663X"
    },
    {
      "affs": [
        0
      ],
      "name": "Thananrat Thongmee",
      "orcid": "0009-0000-6786-9438"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yong Poovorawan",
      "orcid": "0000-0002-2337-6807"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4mqdbvw1fj77p.bib",
  "cited_by": 0,
  "doi": "10.3390/tropicalmed11100291",
  "fulltext_url": "https://europepmc.org/articles/PMC13709610",
  "id": "4mqdbvw1fj77p",
  "issns": [
    "2414-6366"
  ],
  "landing_url": "https://europepmc.org/article/MED/42931476",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2725|Parvovirus B19 Infection Studies"
    ]
  ],
  "openalex": "W7221613809",
  "pdf_url": "https://europepmc.org/articles/PMC13709610?pdf=render",
  "pmcid": "PMC13709610",
  "pmid": "42931476",
  "published": "2026-10-13",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4mqdbvw1fj77p.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42931476",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42931476"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2725|Parvovirus B19 Infection Studies",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Age-Specific Seroprevalence of Human Parvovirus B19 in Thailand: A Cross-Sectional Study Across Four Geographic Regions with Global Comparison.",
  "title_text": "Age-Specific Seroprevalence of Human Parvovirus B19 in Thailand: A Cross-Sectional Study Across Four Geographic Regions with Global Comparison.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:01Z",
  "url": "https://research.draconitic.com/paper/4mqdbvw1fj77p",
  "venue": "Tropical medicine and infectious disease",
  "versions": []
}