{
  "abstract": "Background: Clonal hematopoiesis of indeterminate potential(CHIP), defined by somatic mutations within hematopoietic clones, has emerged as a novel risk factor for cardiovascular disease. While cardiac arrhythmias are a major global health concern, the factors contributing to outcome variability remain unclear. The study aimed to investigate the association between CHIP and mortality in patients with arrhythmias.\n\nMethods: This study analyzed UK Biobank participants hospitalized with arrhythmias who had whole-exome sequencing data. Arrhythmia subtypes were classified using ICD-10 codes. Outcomes, including all-cause, cardiovascular, and cancer-related mortality, were obtained from national registries. CHIP was defined as any CHIP as variant allele fraction(VAF) ≥ 2%, large CHIP as VAF ≥ 10%. Cox regression models adjusted for confounders were used.\n\nResults: Among 53,149 individuals (median age 69 years), 3,315 carried CHIP mutations. Both any and large CHIP were independently associated with higher mortality: adjusted hazard ratios (HRs) for all-cause mortality were 1.26 (1.19–1.34) and 1.44 (1.33–1.55), respectively; for cardiovascular mortality, 1.14 (1.02–1.27) and 1.31 (1.14–1.52); and for cancer-related mortality, 1.36 (1.23–1.51) and 1.65 (1.45–1.87). Associations persisted across arrhythmia subtypes, with the strongest effects in ventricular arrhythmias. In gene-specific analyses, TET2, TP53 and spliceosome genes appeared to be the strongest deleterious genes for all-cause mortality [large TET2 CHIP: HR 1.63 (1.40–1.90); large TP53 CHIP: 1.83 (1.18–2.84); large spliceosome CHIP: HR 1.85 (1.32–2.59)].\n\nConclusions: CHIP is independently associated with increased mortality in patients with arrhythmias across different subtypes. These findings suggest that CHIP may serve as a potential prognostic marker and therapeutic target.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s12967-026-08748-0.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100037 China",
    "Department of Medical Genetics, Center for Medical Genetics, School of Basic Medical Sciences, Peking University, Beijing, 100191 China",
    "Neuroscience Research Institute, Key Laboratory for Neuroscience, Peking University, Ministry of Education of China & National Health Commission of China, Beijing, 100191 China",
    "Autism Research Center, Peking University Health Science Center, Beijing, 100191 China",
    "Centre for Statistics in Medicine and NIHR Biomedical Research Centre Oxford, NDORMS, University of Oxford, Windmill Rd, Oxford, OX3 7LD Oxfordshire UK"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Lei Ding"
    },
    {
      "affs": [
        1
      ],
      "name": "Panhui Tian"
    },
    {
      "affs": [
        0
      ],
      "name": "Fengyuan Yu"
    },
    {
      "affs": [
        0
      ],
      "name": "Zihan Jiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yingjie Qi"
    },
    {
      "affs": [
        0
      ],
      "name": "Aikai Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuandong Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yujing Shen"
    },
    {
      "affs": [
        0
      ],
      "name": "Hongda Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Min Tang",
      "orcid": "0000-0001-7323-3698"
    },
    {
      "affs": [
        1,
        2,
        3
      ],
      "name": "Tianyun Wang"
    },
    {
      "affs": [
        4
      ],
      "name": "Junqing Xie"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4mvkcak3s4cjw.bib",
  "cited_by": 0,
  "doi": "10.1186/s12967-026-08748-0",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13737677/",
  "id": "4mvkcak3s4cjw",
  "issns": [
    "1479-5876"
  ],
  "landing_url": "https://doi.org/10.1186/s12967-026-08748-0",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2720|Acute Myeloid Leukemia Research"
    ]
  ],
  "openalex": "W7201983253",
  "pdf_url": null,
  "pmcid": "PMC13737677",
  "pmid": "42983463",
  "published": "2026-08-08",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/4mvkcak3s4cjw.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:48Z",
      "native_id": "PMC13737677",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12967-026-08748-0"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2720|Acute Myeloid Leukemia Research",
      "subfield": "general"
    }
  ],
  "title": "Effect of clonal hematopoiesis of indeterminate potential on long-term survival in patients with arrhythmias",
  "title_text": "Effect of clonal hematopoiesis of indeterminate potential on long-term survival in patients with arrhythmias",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:48Z",
  "url": "https://research.draconitic.com/paper/4mvkcak3s4cjw",
  "venue": "Journal of Translational Medicine",
  "versions": []
}