{
  "abstract": "Objective: To evaluate the efficacy and safety of LED red light therapy in alleviating primary dysmenorrhea. Methods: A total of 119 patients with primary dysmenorrhea were enrolled in 2022. The intervention was LED red light therapy administered 7 days before menstruation. Clinical outcomes were assessed after three menstrual cycles. Results: After three cycles of treatment, the mean reduction rate in the Visual Analog Scale (VAS) score was 63.62%. The overall effective rate of the device was 98.32%. The total score of the COX Menstrual Symptom Scale decreased by 72.93%, with specific reductions of 72.55% in symptom severity and 73.26% in pain duration. No severe adverse events were reported during the trial. Only one adverse event (0.84%) was considered device-related. Conclusion: LED red light therapy is safe and effective for the treatment of primary dysmenorrhea. Trial registration: ChiCTR2600116460.",
  "abstract_shown": true,
  "affiliations": [
    "Beijing Charmwin Light Medical Technology Co., Ltd., Beijing, China",
    "Department of Gynecology and Obstetrics, The First Affiliated Hospital of Baotou Medical College, Baotou, China",
    "Department of Gynecology, Hebei PetroChina Central Hospital, Langfang, China",
    "Department of Dermatology, Chinese PLA General Hospital, Beijing, China"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Bin Yi"
    },
    {
      "affs": [
        1
      ],
      "name": "Dandan Wang"
    },
    {
      "affs": [
        2
      ],
      "name": "Ling Wei"
    },
    {
      "affs": [
        3
      ],
      "name": "Jun He"
    },
    {
      "name": "Qian Yu"
    },
    {
      "name": "Lei Wu"
    },
    {
      "name": "Yilin Wang"
    },
    {
      "name": "Yajuan Wang"
    },
    {
      "name": "Nan Song"
    },
    {
      "name": "Li Guo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4n2k7avgzv6pp.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0356618",
  "fulltext_url": null,
  "id": "4n2k7avgzv6pp",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0356618",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2741|Laser Applications in Dentistry and Medicine"
    ],
    [
      "plos",
      "/Medicine and health sciences/Clinical medicine/Clinical trials"
    ],
    [
      "plos",
      "/Medicine and health sciences/Clinical medicine/Signs and symptoms/Pain"
    ],
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      "plos",
      "/Medicine and health sciences/Pharmaceutics/Drug therapy/Contraceptive therapy"
    ],
    [
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      "/Medicine and health sciences/Pharmaceutics/Drug therapy/Contraceptive therapy/Oral contraceptive therapy"
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      "/Medicine and health sciences/Pharmacology/Drug research and development/Clinical trials"
    ],
    [
      "plos",
      "/Medicine and health sciences/Women's health/Obstetrics and gynecology/Menstrual abnormalities/Dysmenorrhoea"
    ],
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      "/Physical sciences/Physics/Electromagnetic radiation/Light"
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      "plos",
      "/Research and analysis methods/Clinical trials"
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      "/Research and analysis methods/Research design/Clinical research design/Adverse events"
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      "/Research and analysis methods/Research design/Clinical research design/Symptom scales"
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  "pdf_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0356618&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/4n2k7avgzv6pp.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:02Z",
      "native_id": "10.1371/journal.pone.0356618",
      "source": "plos",
      "url": "https://doi.org/10.1371/journal.pone.0356618"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "plos:clinical trials",
      "subfield": "clinical-trials"
    }
  ],
  "title": "LED red light therapy for relief of primary dysmenorrhea: An open, single-group target value clinical trial",
  "title_text": "LED red light therapy for relief of primary dysmenorrhea: An open, single-group target value clinical trial",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:02Z",
  "url": "https://research.draconitic.com/paper/4n2k7avgzv6pp",
  "venue": "PLOS One",
  "versions": []
}