{
  "abstract": "Craniopharyngiomas comprise two molecularly distinct subtypes: papillary craniopharyngioma (PCP), driven by BRAF V600E mutations, typically presenting as solid, well-circumscribed third ventricular masses in adults; and adamantinomatous craniopharyngioma (ACP), driven by CTNNB1 mutations, featuring cystic-solid architecture with calcifications and hypothalamic adherences. Two representative cases illustrate their radiological and intraoperative differences via the extended endoscopic endonasal approach. Subtype identification through MRI, intraoperative frozen-section analysis, and CSF liquid biopsy is critical, as it directly shapes surgical strategy and postoperative decisions, including BRAF/MEK inhibitor therapy for PCP. Raman spectroscopy holds promise as a future real-time intraoperative discrimination tool.\n\nThe video can be found here: https://stream.cadmore.media/r10.3171/2026.7.FOCVID26127",
  "abstract_shown": true,
  "affiliations": [
    "Division of Neurosurgery, Centre Hospitalier de L’Université de Montréal (CHUM), Québec",
    "Lumedlab, Polytechnique Montréal",
    "Centre de recherche du CHUM (CRCHUM), Montréal; and",
    "Division of Otolaryngology–Head and Neck Surgery, Centre Hospitalier de L’Université de Montréal (CHUM), Québec, Canada"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
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        0
      ],
      "name": "Nesrine Jemel"
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    {
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        2
      ],
      "name": "Ana Bokasova"
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    {
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        1,
        2
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      "name": "Najib Nassiri"
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    {
      "affs": [
        3
      ],
      "name": "Philippe Lavigne"
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    {
      "affs": [
        1,
        2
      ],
      "name": "Frederic Leblond"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Moujahed Labidi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4n59z5adnacqp.bib",
  "cited_by": 0,
  "doi": "10.3171/2026.7.focvid26127",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13698590/",
  "id": "4n59z5adnacqp",
  "issns": [
    "2643-5217"
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  "landing_url": "https://doi.org/10.3171/2026.7.focvid26127",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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    [
      "openalex",
      "2712|Pituitary Gland Disorders and Treatments"
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  "openalex": "W7214008886",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13698590/pdf/?tool=EBI",
  "pmcid": "PMC13698590",
  "pmid": "42936445",
  "published": "2026-10-01",
  "publisher": "American Association of Neurological Surgeons",
  "ris": "https://research.draconitic.com/paper/4n59z5adnacqp.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:27Z",
      "native_id": "PMC13698590",
      "source": "pmc",
      "url": "https://doi.org/10.3171/2026.7.focvid26127"
    },
    {
      "first_seen": "2026-10-30T12:21:45Z",
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      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13698590"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2712|Pituitary Gland Disorders and Treatments",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Endoscopic endonasal management of papillary and adamantinomatous craniopharyngiomas: a comparative operative video with a proposed role for intraoperative Raman spectroscopy",
  "title_text": "Endoscopic endonasal management of papillary and adamantinomatous craniopharyngiomas: a comparative operative video with a proposed role for intraoperative Raman spectroscopy",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:35:26Z",
  "url": "https://research.draconitic.com/paper/4n59z5adnacqp",
  "venue": "Neurosurgical Focus: Video",
  "versions": []
}