{
  "abstract": "Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a novel contributor to atrial fibrillation (AF) pathophysiology. Recent studies suggest that elevated PCSK9 levels may promote AF through multiple mechanisms, including platelet activation, oxidative stress, vascular calcification, and structural atrial remodeling. PCSK9 inhibitors such as alirocumab, evolocumab, and newer agents like inclisiran have shown potential in reducing AF incidence and cardiovascular events, particularly in high‐risk populations. However, evidence from randomized controlled trials with AF as a primary clinical endpoint is limited. Further mechanistic and interventional research is warranted to establish optimized therapeutic strategies targeting PCSK9 in AF prevention and management.",
  "abstract_shown": true,
  "affiliations": [
    "Biotechnology Research Center Pharmaceutical Technology Institute School of Pharmacy Mashhad University of Medical Sciences Mashhad Iran mums.ac.ir",
    "Centre for Research Impact & Outcome Chitkara College of Pharmacy Chitkara University Rajpura Punjab India chitkara.edu.in",
    "Applied Biomedical Research Center Basic Sciences Research Institute Mashhad University of Medical Sciences Mashhad Iran mums.ac.ir",
    "Heart and Vascular Institute Cleveland Clinic Abu Dhabi Abu Dhabi UAE clevelandclinicabudhabi.ae",
    "Next-Generation Translational Nanomedicine Laboratory Department of Pharmaceutical Sciences Dr. Harisingh Gour Vishwavidyalaya (A Central University) Sagar Madhya Pradesh India",
    "University Institute of Pharma Sciences Chandigarh University Mohali Punjab India chandigarhuniversity.ac.in",
    "Pharmaceutical Research Center Pharmaceutical Technology Institute School of Pharmacy Mashhad University of Medical Sciences Mashhad Iran mums.ac.ir"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Amirhossein Sahebkar",
      "orcid": "0000-0002-8656-1444"
    },
    {
      "affs": [
        3
      ],
      "name": "Wael Almahmeed",
      "orcid": "0000-0003-0312-9910"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Prashant Kesharwani",
      "orcid": "0000-0002-0890-769X"
    },
    {
      "affs": [
        6
      ],
      "name": "Tannaz Jamialahmadi",
      "orcid": "0000-0001-9521-3153"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4n92qbbn70t59.bib",
  "cited_by": 0,
  "doi": "10.1155/cdr/7328020",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710888/",
  "id": "4n92qbbn70t59",
  "issns": [
    "1755-5914",
    "1755-5922"
  ],
  "landing_url": "https://doi.org/10.1155/cdr/7328020",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2705|Atrial Fibrillation Management and Outcomes"
    ]
  ],
  "openalex": "W7223957009",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/cdr/7328020",
  "pmcid": "PMC13710888",
  "pmid": "42935110",
  "published": "2026-10-26",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/4n92qbbn70t59.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:45Z",
      "native_id": "PMC13710888",
      "source": "pmc",
      "url": "https://doi.org/10.1155/cdr/7328020"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Atrial Fibrillation Management and Outcomes",
      "subfield": "cardiovascular"
    }
  ],
  "title": "PCSK9 and Atrial Fibrillation: A New Perspective on an Old Problem",
  "title_text": "PCSK9 and Atrial Fibrillation: A New Perspective on an Old Problem",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:45Z",
  "url": "https://research.draconitic.com/paper/4n92qbbn70t59",
  "venue": "Cardiovascular Therapeutics",
  "versions": []
}