{
  "abstract": "Background\n\nCeliac disease is a chronic autoimmune condition with gastrointestinal and extraintestinal symptoms, often impairing physical and psychological well-being. Although a strict gluten-free diet remains the only effective treatment, many patients continue to experience persistent, distressing symptoms. Psychological difficulties-particularly anxiety and depression-are highly prevalent among individuals with celiac disease. Self-compassion has been suggested as a positive psychological resource that may influence the impact of anxiety and depression on psychological and social quality of life in this population. This study aimed to investigate whether self-compassion mediates the relationships between anxiety, depression, and the psychological and social dimensions of quality of life in individuals with celiac disease.Materials and methods\n\nA cross-sectional study was conducted with 198 adult celiac patients recruited from Taleghani Hospital in Tehran, Iran. Participants completed validated measures of anxiety, depression, self-compassion, and quality of life. Mediation analyses were performed using the R lavaan package.Results\n\nSelf-compassion fully mediated the relationship between anxiety and psychological quality of life (P < 0.001), and partially mediated the relationship between depression and psychological quality of life (P < 0.001). Depression significantly predicted social quality of life, but self-compassion showed no significant mediation for social QoL (P > 0.05).Conclusion\n\nSelf-compassion mitigates the impact of anxiety and depression on psychological QoL but not social QoL, while depression strongly impairs social functioning. To enhance QoL in celiac disease, self-compassion therapy could be integrated into clinical care to improve psychological well-being, while cognitive-behavioral or group-based interventions should be explored to address depression's social impact more effectively.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical Psychology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.",
    "Celiac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shiva Mayeli"
    },
    {
      "affs": [
        0
      ],
      "name": "Fatemeh Nazari"
    },
    {
      "affs": [
        1
      ],
      "name": "Mohammad Rostami-Nejad"
    },
    {
      "affs": [
        0
      ],
      "name": "Amir Sam Kianimoghadam"
    },
    {
      "affs": [
        0
      ],
      "name": "Abbas Masjedi Arani"
    },
    {
      "affs": [
        1
      ],
      "name": "Amir Sadeghi"
    },
    {
      "affs": [
        0
      ],
      "name": "Shahab Lotfinia"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4n9jc83zceb70.bib",
  "cited_by": 0,
  "doi": "10.4103/jehp.jehp_1234_25",
  "fulltext_url": "https://europepmc.org/articles/PMC13690101",
  "id": "4n9jc83zceb70",
  "issns": [
    "2277-9531",
    "2319-6440"
  ],
  "landing_url": "https://europepmc.org/article/MED/42924311",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2715|Celiac Disease Research and Management"
    ]
  ],
  "openalex": "W7214915523",
  "pdf_url": "https://europepmc.org/articles/PMC13690101?pdf=render",
  "pmcid": "PMC13690101",
  "pmid": "42924311",
  "published": "2026-09-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4n9jc83zceb70.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:36Z",
      "native_id": "MED:42924311",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42924311"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2715|Celiac Disease Research and Management",
      "subfield": "general"
    }
  ],
  "title": "Exploring the mediating role of self-compassion in the relationship between emotional distress and quality of life in celiac disease.",
  "title_text": "Exploring the mediating role of self-compassion in the relationship between emotional distress and quality of life in celiac disease.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:36Z",
  "url": "https://research.draconitic.com/paper/4n9jc83zceb70",
  "venue": "Journal of education and health promotion",
  "versions": []
}