{
  "abstract": "Objective: To identify risk factors for early-onset sepsis (EOS) in extremely preterm infants.\n\nStudy design: This retrospective study included 554 infants at 22–296/7 weeks’ gestation at Parkland Hospital Dallas, Texas, from 2018 to 2023. Proven EOS was defined by positive blood culture within 72 hours after birth; suspected EOS by ≥5 days of antibiotics despite negative cultures. Remaining infants served as controls. Maternal, neonatal, delivery, and placental characteristics were compared. Low EOS risk was defined as cesarean delivery without labor, rupture of membranes (ROM) at delivery, and no chorioamnionitis.\n\nResults: Prelabor preterm ROM and acute chorioamnionitis on placental pathology were more common among the infants with EOS than those with suspected sepsis and controls (P = 0.02; OR 5.5, 95% CI 1.43–21, P = 0.01, respectively). None of the infants with proven EOS were classified as low risk.\n\nConclusion: Risk assessment for EOS should be promoted to enhance antibiotic stewardship.",
  "abstract_shown": true,
  "affiliations": [
    "University of Texas Southwestern Medical School, Dallas, USA",
    "Department of Pediatrics, Division of Neonatal-Perinatal Medicine, University of Texas Southwestern Medical Center, Dallas, USA",
    "Health System Research, Parkland Health and Hospital System, Dallas, TX USA",
    "Department of Pediatric Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Alessandra Guiterrez"
    },
    {
      "affs": [
        1
      ],
      "name": "Imran Mir"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Katherine Stumpf"
    },
    {
      "affs": [
        1
      ],
      "name": "Leslee M. Roberts"
    },
    {
      "affs": [
        3
      ],
      "name": "Natasha W. Hanners"
    },
    {
      "affs": [
        2
      ],
      "name": "L. Steven Brown"
    },
    {
      "affs": [
        1
      ],
      "name": "Julide Sisman",
      "orcid": "0000-0002-0362-3452"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4na8t0qm5qwef.bib",
  "cited_by": 0,
  "doi": "10.1038/s41372-026-02879-4",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13731132/",
  "id": "4na8t0qm5qwef",
  "issns": [
    "0743-8346",
    "1476-5543"
  ],
  "landing_url": "https://doi.org/10.1038/s41372-026-02879-4",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2735|Neonatal and Maternal Infections"
    ]
  ],
  "openalex": "W7203865026",
  "pdf_url": "https://www.nature.com/articles/s41372-026-02879-4.pdf",
  "pmcid": "PMC13731132",
  "pmid": "42629396",
  "published": "2026-08-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4na8t0qm5qwef.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:21:23Z",
      "native_id": "PMC13731132",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41372-026-02879-4"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2735|Neonatal and Maternal Infections",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Risk assessment of early-onset sepsis in extremely preterm infants: implications for antibiotic stewardship",
  "title_text": "Risk assessment of early-onset sepsis in extremely preterm infants: implications for antibiotic stewardship",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:23Z",
  "url": "https://research.draconitic.com/paper/4na8t0qm5qwef",
  "venue": "Journal of Perinatology",
  "versions": []
}