{
  "abstract": "Metabolic stress is a major determinant of cell fate, particularly during differentiation, when long-lasting adaptations shape cellular responses to subsequent insults. Early-life glycemic instability is increasingly recognized as a stressor capable of programming cardiomyocyte metabolism and vulnerability, yet its direct impact on stress-response pathways during cardiomyocyte differentiation remains poorly defined. Here, we used differentiating H9c2 cardiomyoblasts to model chronic hypoglycemic (2.5 mM), normoglycemic (5 mM), and hyperglycemic (30 mM) conditions as opposing metabolic challenges, and examined their effects on substrate transport, lipid homeostasis, and stress-induced cell death pathways.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy",
    "Department of Life Sciences, University of Siena, Siena, Italy",
    "Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sofia Passaponti"
    },
    {
      "affs": [
        1
      ],
      "name": "Asia Iserani"
    },
    {
      "affs": [
        1
      ],
      "name": "Roberta Romagnoli"
    },
    {
      "affs": [
        1
      ],
      "name": "Laura Cresti"
    },
    {
      "affs": [
        1
      ],
      "name": "Cinzia Del Gaudio"
    },
    {
      "affs": [
        2
      ],
      "name": "Alice Luddi"
    },
    {
      "affs": [
        1
      ],
      "name": "Leonardo Ermini"
    },
    {
      "affs": [
        1
      ],
      "name": "Francesca Ietta"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4ne5kmh87ag1n.bib",
  "cited_by": 0,
  "doi": "10.15698/cst2026.10.321",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659450/?tool=EBI",
  "id": "4ne5kmh87ag1n",
  "issns": [
    "2523-0204"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13659450",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QH301-705.5"
    ],
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "2734|Cardiac Ischemia and Reperfusion"
    ]
  ],
  "openalex": "W7221595455",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659450/pdf/?tool=EBI",
  "pmcid": "PMC13659450",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "Shared Science Publishers OG",
  "ris": "https://research.draconitic.com/paper/4ne5kmh87ag1n.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:25Z",
      "native_id": "PMC:PMC13659450",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13659450"
    },
    {
      "first_seen": "2026-11-06T14:21:07Z",
      "native_id": "0a7f305d65cf4253adea0e747598366d",
      "source": "doaj",
      "url": "https://doi.org/10.15698/cst2026.10.321"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2734|Cardiac Ischemia and Reperfusion",
      "subfield": "general"
    }
  ],
  "title": "Glycemia reprograms substrate transport and shapes divergent stress responses in differentiating H9c2 cells",
  "title_text": "Glycemia reprograms substrate transport and shapes divergent stress responses in differentiating H9c2 cells",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T14:20:21Z",
  "url": "https://research.draconitic.com/paper/4ne5kmh87ag1n",
  "venue": "Cell stress",
  "versions": []
}