{
  "abstract": "Natural products remain vital sources of therapeutics, particularly anti‐infectives, and members of the phylum Myxococcota constitute an especially rich reservoir for their discovery. Based on decades of microbiological efforts, we present 154 new Myxococcota genomes and propose a revised taxonomy expanding the number of described families from 11 to 28 and genera from 32 to 90. Comparison with an equivalent set from the prime source Actinomycetota shows that Myxococcota possess a comparable biosynthetic diversity, underscoring their promise for large‐scale isolation and sequencing efforts. The vast untapped potential reflected in 2,387 uncharacterized gene cluster families is highlighted by genome mining efforts, yielding four validated compounds exhibiting novel chemistry, including myxolutamids and myxopentacins. We show that many Myxococcota‐derived natural products, such as myxolutamid A and two new sorangicin derivatives, are conserved within taxonomic lineages. New described families thus bear high biosynthetic potential underpinning the importance of precise taxonomic classification guiding targeted drug discovery. To facilitate community access and exploration of these data, we provide ABC‐Myxo (https://tools.helmholtz‐hips.de/abc_myxo/), an interactive web‐based atlas of Myxococcota biosynthetic gene clusters.",
  "abstract_shown": true,
  "affiliations": [
    "Center For Bioinformatics Saarland University Saarbrücken Germany",
    "Graduate School of Computer Science Saarland University Saarbrücken Saarland Germany",
    "Research Group Drug Bioinformatics Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) Helmholtz Centre for Infection Research (HZI) Saarbrücken Germany",
    "Department of Microbial Natural Products Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) Helmholtz Centre for Infection Research (HZI) Saarbrücken Germany",
    "German Center for Infection Research (DZIF) Partner Site Hannover‐Braunschweig Braunschweig Germany",
    "PharmaScienceHub Saarbrücken Germany",
    "MyxoTech GmbH Saarbrücken Germany",
    "Chair For Clinical Bioinformatics Center for Bioinformatics Saarland University Saarland University Campus Saarland Germany",
    "Department of Clinical Bioinformatics Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) Helmholtz Centre for Infection Research (HZI) Saarbrücken Germany",
    "Research Group Human‐Microbe Systems Bioinformatics Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) Helmholtz Centre for Infection Research (HZI) Saarbrücken Germany",
    "Department of Biology Far Eastern University Manila Philippines",
    "Department of Computer Science Saarland University Saarbrücken Germany",
    "Leibniz Institute DSMZ – German Collection of Microorganisms and Cell Cultures Braunschweig Germany",
    "Institute of Microbiology Technical University Braunschweig Germany",
    "Medical Faculty Saarland University Homburg Germany"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 26,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Amay Ajaykumar Agrawal",
      "orcid": "0009-0002-6385-2983"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Ronald Garcia",
      "orcid": "0000-0002-0330-0581"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Guangyi Chen"
    },
    {
      "affs": [
        3,
        5
      ],
      "name": "Chantal D. Bader",
      "orcid": "0000-0003-3560-7956"
    },
    {
      "affs": [
        3,
        6
      ],
      "name": "Peter Sullivan",
      "orcid": "0000-0003-1849-9092"
    },
    {
      "affs": [
        3
      ],
      "name": "Alexander Popoff",
      "orcid": "0000-0001-8495-1572"
    },
    {
      "affs": [
        3
      ],
      "name": "Daniel Krug",
      "orcid": "0000-0002-3664-1884"
    },
    {
      "affs": [
        3
      ],
      "name": "Maja Hunter"
    },
    {
      "affs": [
        3
      ],
      "name": "Sebastian Walesch",
      "orcid": "0000-0002-1101-0939"
    },
    {
      "affs": [
        3
      ],
      "name": "Emilia Oueis",
      "orcid": "0000-0002-0228-6394"
    },
    {
      "affs": [
        3
      ],
      "name": "Christine Frank"
    },
    {
      "affs": [
        3
      ],
      "name": "Haowen Zhao",
      "orcid": "0009-0006-4479-9581"
    },
    {
      "affs": [
        3
      ],
      "name": "Joachim J. Hug",
      "orcid": "0000-0003-3420-9286"
    },
    {
      "affs": [
        2
      ],
      "name": "Sebastian Keller",
      "orcid": "0000-0003-4182-5474"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Pascal Hirsch",
      "orcid": "0000-0003-4152-9931"
    },
    {
      "affs": [
        0,
        9
      ],
      "name": "Azat Tagirdzhanov",
      "orcid": "0000-0002-6185-0821"
    },
    {
      "affs": [
        2
      ],
      "name": "Tatiana Malygina"
    },
    {
      "affs": [
        10,
        3
      ],
      "name": "Mary Victory Gutierrez"
    },
    {
      "affs": [
        0,
        11,
        5,
        9
      ],
      "name": "Alexey A. Gurevich",
      "orcid": "0000-0002-5855-3519"
    },
    {
      "affs": [
        4,
        12
      ],
      "name": "Judith Boldt",
      "orcid": "0000-0002-4598-634X"
    },
    {
      "affs": [
        12
      ],
      "name": "Boyke Bunk",
      "orcid": "0000-0002-8420-8161"
    },
    {
      "affs": [
        4,
        13,
        12
      ],
      "name": "Jörg Overmann",
      "orcid": "0000-0003-3909-7201"
    },
    {
      "affs": [
        4,
        13,
        12
      ],
      "name": "Ulrich Nübel",
      "orcid": "0000-0003-3131-1656"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Andreas Keller",
      "orcid": "0000-0002-5361-0895"
    },
    {
      "affs": [
        0,
        14,
        5,
        2
      ],
      "name": "Olga V. Kalinina",
      "orcid": "0000-0002-9445-477X"
    },
    {
      "affs": [
        3,
        4,
        5
      ],
      "name": "Rolf Müller",
      "orcid": "0000-0002-1042-5665"
    }
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  "bibtex": "https://research.draconitic.com/paper/4nhx6rzkj0j70.bib",
  "cited_by": 5,
  "doi": "10.1002/advs.76919",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13445942/",
  "id": "4nhx6rzkj0j70",
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  "landing_url": "https://doi.org/10.1002/advs.76919",
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  "pmcid": "PMC13445942",
  "pmid": "42559960",
  "published": "2026-08-06",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/4nhx6rzkj0j70.ris",
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  "subjects": [
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      "field": "biology",
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    {
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      "origin": "openalex:2736|Microbial Natural Products and Biosynthesis",
      "subfield": "pharmacology-toxicology"
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  ],
  "title": "Unveiling the Taxonomic Diversity and Unprecedented Biosynthetic Treasure of the Phylum Myxococcota",
  "title_text": "Unveiling the Taxonomic Diversity and Unprecedented Biosynthetic Treasure of the Phylum Myxococcota",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:11Z",
  "url": "https://research.draconitic.com/paper/4nhx6rzkj0j70",
  "venue": "Advanced Science",
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}