{
  "abstract": "The effect of diet on genetic regulation in humans remains largely unexplored. Here, we investigate gene-diet interactions in a unique group of healthy individuals (N = 200) who alternate between omnivory and dietary restriction of animal products for religious reasons. Using longitudinal proteomic and genotype data, we identify diet-responsive cis-pQTLs and highlight regulatory effects on LBR and MSRA, proteins involved in cholesterol and methionine metabolism respectively. LBR-associated cis-pQTL rs74148404 colocalizes with obesity exclusively under dietary restriction, suggesting diet-dependent modulation of genetic risk. We also show that a diet-dependent cis-pQTL for metabolic regulator FGF21 colocalizes with eosinophil and platelet traits pointing to diet-sensitive immunometabolic signalling. By parallel profiling of a continuously omnivorous control group (N = 211), we uncover seasonally dynamic genetic regulation for proteins linked to apoptosis in immune system pathways (MAVS, CASP3, PDLIM7, IL12RB1), effects likely masked by animal product restriction. These findings reveal dynamic diet- and season-sensitive regulatory mechanisms with implications for precision nutrition and individualized disease prevention strategies, and underscore the need to integrate environmental context into genetic studies of health and disease.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Alexandros Simistiras"
    },
    {
      "name": "Ozvan Bocher"
    },
    {
      "name": "Christina Emmanouil"
    },
    {
      "name": "Anargyros Skoulakis"
    },
    {
      "name": "Stavros Glentis"
    },
    {
      "name": "Nikolaos Scarmeas"
    },
    {
      "name": "Eleftheria Zeggini"
    },
    {
      "name": "Konstantinos Rouskas"
    },
    {
      "name": "Antigone Dimas"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4nn6w7q1qk25n.bib",
  "cited_by": 1,
  "doi": "10.1038/s41467-026-76379-6",
  "fulltext_url": null,
  "id": "4nn6w7q1qk25n",
  "issns": [
    "2041-1723",
    "2041-1723"
  ],
  "landing_url": "https://hal.science/hal-05773979v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.gen"
    ],
    [
      "hal",
      "2.sdv.gen.gh"
    ],
    [
      "openalex",
      "1311|Nutrition, Genetics, and Disease"
    ]
  ],
  "openalex": "W4413271922",
  "pdf_url": "https://hal.science/hal-05773979/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-08",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/4nn6w7q1qk25n.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:45Z",
      "native_id": "hal-05773979",
      "source": "hal",
      "url": "https://hal.science/hal-05773979v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.gen",
      "subfield": "genetics-genomics"
    },
    {
      "field": "medicine",
      "origin": "hal:2.sdv.gen.gh",
      "subfield": "human-genetics"
    }
  ],
  "title": "Diet-responsive proteogenomic effects following short-term restriction of animal products in humans",
  "title_text": "Diet-responsive proteogenomic effects following short-term restriction of animal products in humans",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:45Z",
  "url": "https://research.draconitic.com/paper/4nn6w7q1qk25n",
  "venue": "Nature Communications",
  "versions": []
}