{
  "abstract": "Lynch syndrome (LS), a common inherited genetic condition predisposing to cancer, provides a unique model to study immune surveillance at the earliest stages of tumorigenesis. A hallmark of LS carcinogenesis is the generation of highly immunogenic neoantigens, yet the transcriptomic states of the T cells that recognize them remain poorly understood. Here, we characterize neoantigen-specific T cells from LS carriers using functional assays, single-cell RNA/T cell receptor (TCR) sequencing, and repertoire integration with existing large datasets. Recurrent neoantigens elicit strong immune responses, with neoantigen-specific T cells mediating cytotoxicity against tumor organoids. Single-cell analysis reveals oligoclonal expansions spanning effector and memory states with enrichment for exhausted subsets among cancer survivors and retention of polyfunctional effectors in cancer-free carriers. Cross-cohort analysis identifies public TCR clonotypes in circulation that overlap with pre-cancer and tumor tissue repertoires. Together, these findings define the architecture of circulating neoantigen-specific immune memory in LS and highlight public TCRs as candidates for immune monitoring and immunoprevention.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA",
    "Institute of Immunology, Medical University of Vienna, Vienna, Austria",
    "Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA",
    "Department of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Fahriye Duzagac"
    },
    {
      "affs": [
        0
      ],
      "name": "Nan Deng"
    },
    {
      "affs": [
        0
      ],
      "name": "Jinling Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Supriya Nagaraju"
    },
    {
      "affs": [
        1
      ],
      "name": "Peter Steinberger"
    },
    {
      "affs": [
        2
      ],
      "name": "Alexandre Reuben"
    },
    {
      "affs": [
        0
      ],
      "name": "Krishna M. Sinha"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Eduardo Vilar"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4np2sn6rz9jkk.bib",
  "cited_by": 0,
  "doi": "10.1016/j.xcrm.2026.103057",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710556/",
  "id": "4np2sn6rz9jkk",
  "issns": [
    "2666-3791"
  ],
  "landing_url": "https://doi.org/10.1016/j.xcrm.2026.103057",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2730|Cancer Immunotherapy and Biomarkers"
    ]
  ],
  "openalex": "W7213548959",
  "pdf_url": null,
  "pmcid": "PMC13710556",
  "pmid": "42759506",
  "published": "2026-09-18",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/4np2sn6rz9jkk.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:30Z",
      "native_id": "PMC13710556",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.xcrm.2026.103057"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Cancer Immunotherapy and Biomarkers",
      "subfield": "oncology"
    }
  ],
  "title": "Characterization of circulating neoantigen-specific T cell responses and public T cell receptors shaping immune memory in Lynch syndrome carriers",
  "title_text": "Characterization of circulating neoantigen-specific T cell responses and public T cell receptors shaping immune memory in Lynch syndrome carriers",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:30Z",
  "url": "https://research.draconitic.com/paper/4np2sn6rz9jkk",
  "venue": "Cell Reports Medicine",
  "versions": []
}