{
  "abstract": "Background/Aim: Expression of the gene encoding collagen type I α1 chain (COL1A1) in cancer tissue primarily results in production of the pro-form of COL1A1, which can be released into the bloodstream. This study aimed to investigate whether plasma levels of pro-COL1A1 are associated with clinicopathological characteristics and long-term survival in patients with colorectal cancer (CRC).\n\nMaterials and Methods: Plasma levels of pro-pro-COL1A1 were measured in 148 patients with CRC and 28 healthy controls using an enzyme-linked immunosorbent assay (ELISA).\n\nResults: Plasma levels of pro-COL1A1 were significantly lower in patients with CRC compared with healthy controls (p<0.001). Lower levels were also observed in men compared with women. Kaplan-Meier survival analysis demonstrated that a low plasma level of pro-COL1A1 was associated with poorer overall survival considering the entire cohort, as well as in subgroups of patients with colon cancer, depth of tumor invasion T3+T4, node-negative (N0) disease and in females.\n\nConclusion: These findings suggest that plasma levels of pro-COL1A1 may serve as a prognostic biomarker for long-term survival in patients with CRC.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical Diagnostics, School of Health and Welfare, Jönköping University, Jönköping, Sweden",
    "Department of Laboratory Medicine and Pathology, Ryhov Hospital, Jönköping, Sweden",
    "Department of Laboratory, Vinmec Danang International General Hospital, Danang, Vietnam",
    "Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden",
    "Clinical Department of Surgery in Linköping, Region Östergötland, Sweden",
    "Department of Surgery, Ryhov Hospital, Region Jönköping County, Jönköping, Sweden",
    "Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "JAN DIMBERG"
    },
    {
      "affs": [
        1
      ],
      "name": "LEVAR SHAMOUN"
    },
    {
      "affs": [
        2
      ],
      "name": "SON DINH AN TRUONG"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "KALLE LANDERHOLM"
    },
    {
      "affs": [
        3,
        5
      ],
      "name": "EMMA DRUVEFORS"
    },
    {
      "affs": [
        6
      ],
      "name": "DICK WÅGSÄTER"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4npkyh4pmpwcj.bib",
  "cited_by": 0,
  "doi": "10.21873/invivo.14501",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13723979/",
  "id": "4npkyh4pmpwcj",
  "issns": [
    "0258-851X",
    "1791-7549"
  ],
  "landing_url": "https://doi.org/10.21873/invivo.14501",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2730|Colorectal Cancer Treatments and Studies"
    ]
  ],
  "openalex": "W7224381616",
  "pdf_url": "https://iv.iiarjournals.org/content/invivo/40/6/3630.full.pdf",
  "pmcid": "PMC13723979",
  "pmid": "42957271",
  "published": "2026-10-29",
  "publisher": "International Institute of Anticancer Research",
  "ris": "https://research.draconitic.com/paper/4npkyh4pmpwcj.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:22:31Z",
      "native_id": "PMC13723979",
      "source": "pmc",
      "url": "https://doi.org/10.21873/invivo.14501"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Colorectal Cancer Treatments and Studies",
      "subfield": "oncology"
    }
  ],
  "title": "Significance of Plasma Pro-collagen Type I α1 Chain in Patients With Colorectal Cancer",
  "title_text": "Significance of Plasma Pro-collagen Type I α1 Chain in Patients With Colorectal Cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:20:42Z",
  "url": "https://research.draconitic.com/paper/4npkyh4pmpwcj",
  "venue": "In Vivo",
  "versions": []
}