{
  "abstract": "Introduction\n\nSepsis-induced immune dysregulation, characterized by T-cell loss, is associated with poor outcomes. This study investigated the association between early peripheral T-lymphocyte subset profiles and 28 day mortality in patients with sepsis.Methods\n\nIn this single-center retrospective cohort study, 60 critically ill patients with sepsis and 30 healthy controls were included. Patients with sepsis were classified as 28 day survivors (n = 30) or non-survivors (n = 30). Peripheral T-lymphocyte subset percentages (CD3⁺, CD4⁺, and CD8⁺) were measured by flow cytometry within 24 h of ICU admission.Results\n\nCompared with healthy controls, patients with sepsis had lower CD3⁺ (55.23±9.15%vs. 68.12±8.04%) and CD4⁺ T-cell percentages (30.88±10.52%vs. 40.15±7.21%) and a lower CD4⁺/CD8⁺ ratio (all p < 0.001). Non-survivors had lower CD3⁺ and CD4⁺ T-cell percentages than survivors (both p < 0.001). In multivariable logistic regression, lower CD4⁺ T-cell percentage (OR = 0.85, 95% CI 0.77-0.94; p = 0.002) and higher APACHE II score (OR = 1.42, 95% CI 1.18-1.71; p < 0.001) were independently associated with 28-day mortality. Adding CD4⁺ T-cell percentage to APACHE II increased the area under the receiver operating characteristic curve from 0.86 to 0.91 (p = 0.03).Conclusion\n\nEarly reduction in peripheral CD4⁺ T-cell percentage was independently associated with 28 day mortality in this selected cohort. CD4⁺ T-cell assessment may provide incremental prognostic information beyond APACHE II, but external validation in larger prospective cohorts is required.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Infectious Disease, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, Xianning, Hubei, China.",
    "Department of Emergency/General Practice, Wuhan University of Science and Technology Affiliated Geriatric Hospital, Wuhan, Hubei, China.",
    "Intensive Care Unit, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.",
    "Pediatric Intensive Care Unit, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.",
    "The Second Affiliated Clinical College of Wuhan University of Science and Technology, Wuhan, Hubei, China.",
    "Intensive Care Unit, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address: fangmh@tjh.tjmu.edu.cn."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Deng Pan"
    },
    {
      "affs": [
        1
      ],
      "name": "Pin Peng"
    },
    {
      "affs": [
        2
      ],
      "name": "Yu Fang"
    },
    {
      "affs": [
        2
      ],
      "name": "Jun Lu"
    },
    {
      "affs": [
        3
      ],
      "name": "Wendi Zhang"
    },
    {
      "affs": [
        4
      ],
      "name": "Shanshan Hu"
    },
    {
      "affs": [
        5
      ],
      "name": "Minghao Fang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4nya6ys5kzbsz.bib",
  "cited_by": 0,
  "doi": "10.1016/j.clinsp.2026.101173",
  "fulltext_url": "https://europepmc.org/articles/PMC13693353",
  "id": "4nya6ys5kzbsz",
  "issns": [
    "1807-5932",
    "1980-5322"
  ],
  "landing_url": "https://europepmc.org/article/MED/42880129",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Sepsis Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7221795859",
  "pdf_url": "https://europepmc.org/articles/PMC13693353?pdf=render",
  "pmcid": "PMC13693353",
  "pmid": "42880129",
  "published": "2026-10-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4nya6ys5kzbsz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:46Z",
      "native_id": "MED:42880129",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42880129"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Sepsis Diagnosis and Treatment",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Association of early CD4⁺ T-lymphocyte depletion with 28 day mortality in sepsis: a retrospective single-center cohort study.",
  "title_text": "Association of early CD4⁺ T-lymphocyte depletion with 28 day mortality in sepsis: a retrospective single-center cohort study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:46Z",
  "url": "https://research.draconitic.com/paper/4nya6ys5kzbsz",
  "venue": "Clinics (Sao Paulo, Brazil)",
  "versions": []
}