{
  "abstract": "Previous editions of the European guidelines for the management of chronic lymphocytic leukemia (CLL) were developed by experts in CLL under the auspices of the European Society for Medical Oncology (ESMO). These previous editions have served as a reference text for many physicians caring for patients with CLL. The current, 2026 edition, represents the new, updated guidelines that, for the first time (and in agreement with ESMO), were written on behalf of the European Hematology Association (EHA), which will be solely responsible for subsequent editions, published annually to keep pace of the fast-moving field of CLL research and clinical applications. The new guidelines support approaching the management of CLL in a more holistic fashion, from the initial diagnosis (including active surveillance) to treatment need, with particular emphasis on the interplay between disease- and patient-specific criteria for decision-making, to the latest stage of possible Richter transformation, which is now specifically mentioned in the title of the guidelines. These new recommendations are the result of a consensus reached among medical experts from several European countries and, for the first time, have involved patient advocacy representatives, which is in line with EHA standard operating procedures for clinical practice guideline development. Updates in terms of treatment options include the recently European Medicines Agency-approved, time-limited combination therapy acalabrutinib and venetoclax ± obinutuzumab as first-line treatment, and continuous pirtobrutinib for patients exposed to covalent Bruton's tyrosine kinase inhibitors in the relapsed/refractory setting.",
  "abstract_shown": true,
  "affiliations": [
    "Department I for Internal Medicine, Center of Integrated Oncology Aachen, Bonn, Cologne, Duesseldorf University of Cologne Cologne Germany",
    "IRCCS Ospedale San Raffaele Comprehensive Cancer Center Milano Italy",
    "Medical School Università Vita‐Salute San Raffaele Milano Italy",
    "Department of Hematology, University Hospital Vall d'Hebron Vall d'Hebron Institute of Oncology (VHIO) Barcelona Spain",
    "Department of Haematology, Cancer Services University Hospital Limerick Limerick Ireland",
    "Limerick Digital Cancer Research Center, Health Research Institute, School of Medicine University of Limerick Limerick Ireland",
    "Division of Hematology Luzerner Kantonsspital Luzern Switzerland",
    "University Hospital of Clermont‐Ferrand and Université Clermont Auvergne Clermont‐Ferrand France",
    "Department of Hematology, Cancer Center Amsterdam Amsterdam University Medical Centers, Amstewrdam, Netherlands, also on behalf of HOVON",
    "Department of Hematology, Rigshospitalet Copenhagen University Hospital Copenhagen Denmark",
    "CEITEC and Department of Internal Medicine, Hematology and Oncology, Faculty of Medicine Masaryk University and University Hospital Brno Brno Czech Republic",
    "Department of Hematology, Medical University of Lodz, and Department of General Hematology and Internal Medicine, Lodz Copernicus Memorial Hospital Lodz Poland",
    "Department of Oncology University of Oxford Oxford United Kingdom",
    "Institute of Applied Biosciences Centre for Research and Technology Hellas Thessaloniki Greece",
    "Hematology unit Bnai‐Zion Medical Center, and the Ruth and Bruce Rappaport Faculty of Medicine Technion Haifa Israel",
    "Leukaemia Care, One Birch Court Blackpole East Worcester United Kingdom"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Barbara F. Eichhorst",
      "orcid": "0000-0001-9990-6918"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Paolo Ghia",
      "orcid": "0000-0003-3750-7342"
    },
    {
      "affs": [
        3
      ],
      "name": "Francesc Bosch",
      "orcid": "0000-0001-9241-2886"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Ruth Clifford",
      "orcid": "0009-0003-8727-2550"
    },
    {
      "affs": [
        6
      ],
      "name": "Michael Gregor"
    },
    {
      "affs": [
        7
      ],
      "name": "Romain Guièze",
      "orcid": "0000-0001-7563-580X"
    },
    {
      "affs": [
        8
      ],
      "name": "Arnon Philip Kater",
      "orcid": "0000-0003-3190-1891"
    },
    {
      "affs": [
        9
      ],
      "name": "Carsten U. Niemann",
      "orcid": "0000-0001-9880-5242"
    },
    {
      "affs": [
        10
      ],
      "name": "Sarka Pospisilova"
    },
    {
      "affs": [
        11
      ],
      "name": "Tadeusz Robak",
      "orcid": "0000-0002-3411-6357"
    },
    {
      "affs": [
        12
      ],
      "name": "Anna Schuh",
      "orcid": "0000-0002-3938-8490"
    },
    {
      "affs": [
        13
      ],
      "name": "Kostas Stamatopoulos",
      "orcid": "0000-0001-8529-640X"
    },
    {
      "affs": [
        14
      ],
      "name": "Tamar Tadmor",
      "orcid": "0000-0002-3435-8612"
    },
    {
      "affs": [
        15
      ],
      "name": "Nick York"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4p0s108mzvxex.bib",
  "cited_by": 23,
  "doi": "10.1002/hem3.70403",
  "fulltext_url": null,
  "id": "4p0s108mzvxex",
  "issns": [
    "2572-9241"
  ],
  "landing_url": "https://doi.org/10.1002/hem3.70403",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2716|Chronic Lymphocytic Leukemia Research"
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      "2720|Chronic Lymphocytic Leukemia Research"
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  "openalex": "W7164338050",
  "pdf_url": null,
  "pmcid": "PMC13254007",
  "pmid": "42293463",
  "published": "2026-06-01",
  "publisher": "Wolters Kluwer",
  "ris": "https://research.draconitic.com/paper/4p0s108mzvxex.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:54Z",
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      "url": "https://doi.org/10.1002/hem3.70403"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Chronic Lymphocytic Leukemia Research",
      "subfield": "human-genetics"
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  ],
  "title": "EHA Guidelines on management of chronic lymphocytic leukemia and Richter transformation",
  "title_text": "EHA Guidelines on management of chronic lymphocytic leukemia and Richter transformation",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T13:20:50Z",
  "url": "https://research.draconitic.com/paper/4p0s108mzvxex",
  "venue": "HemaSphere",
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