{
  "abstract": "Olfactory sensory neurons comprise a population of highly heterogeneous subtypes. One important mechanism contributing to neuronal diversity is post-transcriptional regulation, in which isoform heterogeneity is an important component. Comprehensive profiling of transcript isoforms in olfactory sensory neurons is therefore essential for understanding the molecular mechanisms underlying their diversity. By integrating single-cell long-read sequencing with conventional 3’ RNA sequencing, we demonstrated that these neurons contain extensive isoform diversity. We identified widespread UTR remodeling and isoform switching associated with developmental stage and spatial projection pattern, providing compelling evidence for the crucial regulatory mechanism underlying OSN diversity. Furthermore, we observed co-expression of multiple isoforms from the same olfactory receptor gene within individual olfactory sensory neurons, including some predicted to encode complete transmembrane domains. Together, these data provide a resource and framework for studying how specific isoforms contribute to olfactory sensory neuron identity, axon targeting, and the maintenance of singular olfactory receptor expression.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory of Biocontrol, Innovation Center for Evolutionary Synthetic Biology, School of Life Sciences, Sun Yat-sen University, Guangzhou, China",
    "Shenzhen Key Laboratory of Synthetic Genomics, Guangdong Provincial Key Laboratory of Synthetic Genomics, State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yicong Xu"
    },
    {
      "affs": [
        1
      ],
      "name": "Jiawen Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Wasiyu Yuan"
    },
    {
      "affs": [
        0
      ],
      "name": "Tao Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Peiyu Shi"
    },
    {
      "affs": [
        0
      ],
      "name": "Tingting Huang"
    },
    {
      "affs": [
        1
      ],
      "name": "Qing Ma"
    },
    {
      "affs": [
        0
      ],
      "name": "Jin Xu",
      "orcid": "0000-0003-0944-9835"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4p1pbdbff5qvh.bib",
  "cited_by": 0,
  "doi": "10.1038/s42003-026-10544-x",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13724654/",
  "id": "4p1pbdbff5qvh",
  "issns": [
    "2399-3642"
  ],
  "landing_url": "https://doi.org/10.1038/s42003-026-10544-x",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1312|Single-cell and spatial transcriptomics"
    ]
  ],
  "openalex": "W7165666500",
  "pdf_url": null,
  "pmcid": "PMC13724654",
  "pmid": "42342898",
  "published": "2026-06-24",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/4p1pbdbff5qvh.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:11Z",
      "native_id": "PMC13724654",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s42003-026-10544-x"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Single-cell and spatial transcriptomics",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Single-cell long-read profiling of olfactory sensory neuron differentiation and diversity",
  "title_text": "Single-cell long-read profiling of olfactory sensory neuron differentiation and diversity",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:04Z",
  "url": "https://research.draconitic.com/paper/4p1pbdbff5qvh",
  "venue": "Communications Biology",
  "versions": []
}