{
  "abstract": "Hyperuricemia (HUA) is a chronic metabolic disorder whose prevalence continues to rise, whereas available urate-lowering drugs are limited by safety and tolerability concerns. Resveratrol (Res) exhibits urate-lowering activity, but its oral bioavailability is below 1%, prompting investigation of its potential interactions with the gut microbiota. Here, hyperuricemic mice induced by potassium oxonate plus high-fructose intake were treated with Res (20, 40, or 80 mg/kg) or benzbromarone (20 mg/kg), and 16S rDNA sequencing, PICRUSt2 functional prediction, untargeted fecal metabolomics, and multi-omics network analysis were integrated to characterize the underlying mechanisms. Res (80 mg/kg) significantly lowered serum uric acid, inhibited xanthine oxidase and adenosine deaminase activities, improved renal injury, suppressed pro-inflammatory cytokines, and up-regulated colonic barrier genes with reduced serum lipopolysaccharide. Res normalized inflated microbial richness, restored Akkermansia abundance, and PICRUSt2 prediction indicated down-regulation of the microbial purine-metabolism gene families XOD/XDH and UOX by 29.4% and 85.9%, respectively. Metabolomics identified 41 shared differential metabolites including eicosanoid lipid mediators and glycerophospholipids. Multi-omics exploratory network analysis suggested Akkermansia as a potential hub node associated with microbial remodeling, eicosanoid modulation, and host urate phenotypes, which may represent a \"urate-production suppression plus microbiota-metabolism axis regulation\" mode of action, providing preclinical evidence for Res as a candidate dietary intervention against HUA.",
  "abstract_shown": true,
  "affiliations": [
    "Key Laboratory of Development and Utilization of Food and Medicinal Resources, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.",
    "Engineering Research Center of Development and Utilization of Food and Drug Homologous Resources, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.",
    "Yunnan Key Laboratory of Precision Nutrition and Personalized Food Manufacturing, Yunnan Agricultural University, Kunming 650201, China.",
    "College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Yan Wang"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jing Xie"
    },
    {
      "affs": [
        1,
        2,
        3
      ],
      "name": "Zuoming Cao"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Xiaoyu Gao",
      "orcid": "0009-0003-1468-8184"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Zuoting Yang"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Yang Tian"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Jun Sheng"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Lei Peng",
      "orcid": "0000-0003-4315-4897"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4pd1vztd52r7z.bib",
  "cited_by": 0,
  "doi": "10.3390/foods15203686",
  "fulltext_url": "https://europepmc.org/articles/PMC13704755",
  "id": "4pd1vztd52r7z",
  "issns": [
    "2304-8158"
  ],
  "landing_url": "https://europepmc.org/article/MED/42940323",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2727|Gout, Hyperuricemia, Uric Acid"
    ]
  ],
  "openalex": "W7222602676",
  "pdf_url": "https://europepmc.org/articles/PMC13704755?pdf=render",
  "pmcid": "PMC13704755",
  "pmid": "42940323",
  "published": "2026-10-16",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4pd1vztd52r7z.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:12Z",
      "native_id": "MED:42940323",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42940323"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2727|Gout, Hyperuricemia, Uric Acid",
      "subfield": "general"
    }
  ],
  "title": "Resveratrol Ameliorates Hyperuricemia in Association with Remodeling of the Gut Microbiota-Metabolism Axis: An Integrated 16S rDNA Sequencing and Fecal Metabolomics Study.",
  "title_text": "Resveratrol Ameliorates Hyperuricemia in Association with Remodeling of the Gut Microbiota-Metabolism Axis: An Integrated 16S rDNA Sequencing and Fecal Metabolomics Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:12Z",
  "url": "https://research.draconitic.com/paper/4pd1vztd52r7z",
  "venue": "Foods (Basel, Switzerland)",
  "versions": []
}