{
  "abstract": "Brain glymphatic system function as measured by diffusion tensor image analysis along the perivascular space (DTI-ALPS) index has been associated with brain disorders, but its association with mortality and other diseases remains underexplored. This prospective study included 34,268 participants from the UK Biobank with MRI data collected since August 2014. The DTI-ALPS indices‌ of the left and right hemispheres and the average index were calculated‌. The incident mortality and morbidity were defined as the death and disease (cancer, cardiovascular, respiratory, digestive, and neurodegenerative disease) reported between the MRI collection date and December 2021. Cox proportional hazard regression analyses were used to assess the association of DTI-ALPS indices with all-cause and cause-specific mortality and morbidity. We found that a higher DTI-ALPS index, indicated better glymphatic function, was associated with reduced risks of all-cause mortality (HR, 95% CI: 0.85, 0.78-0.93; P < 0.001), cardiovascular disease (CVD)-specific mortality (HR, 95% CI: 0.77, 0.63-0.93; P = 0.01), and neurodegenerative disease-specific mortality (HR, 95% CI: 0.56, 0.37-0.84; P = 0.01). Furthermore, an elevated DTI-ALPS index was associated with reduced risks of CVD (HR, 95% CI: 0.92, 0.89-0.96; P < 0.001) and neurodegenerative disease (HR, 95% CI: 0.68, 0.58-0.80; P < 0.001). The findings deepen the understanding of the role of brain glymphatic system in health.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.",
    "Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, China.",
    "Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, UNSW, Sydney, 1466, Australia.",
    "Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.",
    "Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.",
    "Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Ministry of Education, Shanghai, China.",
    "Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China. jintai_yu@fudan.edu.cn."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ya-Ru Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhi-Bo Wang",
      "orcid": "0009-0000-1152-6591"
    },
    {
      "affs": [
        0
      ],
      "name": "Shu-Yi Huang",
      "orcid": "0000-0001-6573-6025"
    },
    {
      "affs": [
        2
      ],
      "name": "Jing Du"
    },
    {
      "affs": [
        3
      ],
      "name": "Yan Fu"
    },
    {
      "affs": [
        3
      ],
      "name": "Pei-Yang Gao",
      "orcid": "0009-0002-7559-1215"
    },
    {
      "affs": [
        3
      ],
      "name": "Lan Tan",
      "orcid": "0000-0002-8759-7588"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Jian-Feng Feng",
      "orcid": "0000-0001-5987-2258"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Wei Cheng",
      "orcid": "0000-0003-1118-1743"
    },
    {
      "affs": [
        6
      ],
      "name": "Jin-Tai Yu",
      "orcid": "0000-0002-2532-383X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4pevh5eb008m0.bib",
  "cited_by": 0,
  "doi": "10.1038/s41398-026-04381-z",
  "fulltext_url": "https://europepmc.org/articles/PMC13752321",
  "id": "4pevh5eb008m0",
  "issns": [
    "2158-3188"
  ],
  "landing_url": "https://europepmc.org/article/MED/43009471",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
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      "openalex",
      "2728|Cerebrospinal fluid and hydrocephalus"
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  "pdf_url": "https://europepmc.org/articles/PMC13752321?pdf=render",
  "pmcid": "PMC13752321",
  "pmid": "43009471",
  "published": "2026-08-14",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/4pevh5eb008m0.ris",
  "sources": [
    {
      "first_seen": "2026-11-12T15:22:43Z",
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      "url": "https://europepmc.org/article/MED/43009471"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Cerebrospinal fluid and hydrocephalus",
      "subfield": "neurology"
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  ],
  "title": "Association of brain glymphatic system with risk of incident mortality and morbidity.",
  "title_text": "Association of brain glymphatic system with risk of incident mortality and morbidity.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-15T12:21:45Z",
  "url": "https://research.draconitic.com/paper/4pevh5eb008m0",
  "venue": "Translational psychiatry",
  "versions": []
}