{
  "abstract": "A fundamental challenge in drug development is the frequent failure of early laboratory research to translate into clinical benefit. One promising solution is to confirm findings from exploratory single-laboratory studies across multiple laboratories before clinical testing. We investigated this approach following the conduct of preclinical multi-laboratory studies across different fields of medicine. For this, we evaluated effect sizes, experimental rigor, and a set of criteria to identify determinants of confirmation success. When tested under increased rigor, only a fraction of multi-laboratory studies confirmed the initial results. The underlying effect size reduction was associated with outcome-relevant experimental differences between exploratory and confirmatory stages. In summary, multi-laboratory studies proved highly informative and served as an effective filter for promising treatments.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 39,
  "authors": [
    {
      "name": "P. Pellegrini"
    },
    {
      "name": "S. C. Rotter"
    },
    {
      "name": "M. Arroyo-Araujo"
    },
    {
      "name": "C. F. D. Carneiro"
    },
    {
      "name": "N. I. Drude"
    },
    {
      "name": "L. Martinez Gamboa"
    },
    {
      "name": "A. Banito"
    },
    {
      "name": "N. Bernhardt"
    },
    {
      "name": "A.-L. Boulesteix"
    },
    {
      "name": "F. Buttgereit"
    },
    {
      "name": "A. Dempfle"
    },
    {
      "name": "N. Duran-Hernandez"
    },
    {
      "name": "T. Gaber"
    },
    {
      "name": "M. Groettrup"
    },
    {
      "name": "B. Habelt"
    },
    {
      "name": "B. Haller"
    },
    {
      "name": "H. Hamza"
    },
    {
      "name": "S. Hettmer"
    },
    {
      "name": "A. Kliesow Remes"
    },
    {
      "name": "S. Kobold"
    },
    {
      "name": "M. Kochan"
    },
    {
      "name": "F. Konietschke"
    },
    {
      "name": "L. H. Lehmann"
    },
    {
      "name": "M. Löhning"
    },
    {
      "name": "A. Matzen"
    },
    {
      "name": "M. W. Meinhardt"
    },
    {
      "name": "H. Morrison"
    },
    {
      "name": "O. J. Müller"
    },
    {
      "name": "O. Planz"
    },
    {
      "name": "G. H. S. Richter"
    },
    {
      "name": "L. B. Riecken"
    },
    {
      "name": "S. K. Rosahl"
    },
    {
      "name": "K. Rubarth"
    },
    {
      "name": "K. Schmidt-Bleek"
    },
    {
      "name": "L. Schuler"
    },
    {
      "name": "A. Sharma"
    },
    {
      "name": "I. Skorodumov"
    },
    {
      "name": "R. Spanagel"
    },
    {
      "name": "I. Teichert-von Lüttichau"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4pqczn514bf8p.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.21.753112",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.21.753112v1.full",
  "id": "4pqczn514bf8p",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.21.753112v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "scientific communication and education"
    ],
    [
      "openalex",
      "3404|Animal testing and alternatives"
    ]
  ],
  "openalex": "W7214339474",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.21.753112v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4pqczn514bf8p.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:24:31Z",
      "native_id": "10.64898/2026.09.21.753112",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.21.753112v3"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:scientific communication and education",
      "subfield": "general"
    }
  ],
  "title": "Multi-Lab Testing of Early Preclinical Discoveries Identifies Promising Treatments",
  "title_text": "Multi-Lab Testing of Early Preclinical Discoveries Identifies Promising Treatments",
  "type": "preprint",
  "updated_at": "2026-11-01T00:20:36Z",
  "url": "https://research.draconitic.com/paper/4pqczn514bf8p",
  "venue": "bioRxiv",
  "versions": []
}