{
  "abstract": "Because of the paucity of pattern-generating recurrent excitation in the CA1 hippocampal region, place field sequences are assumed to be inherited from upstream regions. Alternatively, disinhibition may play a role in shaping pyramidal cell activity. We propose a model of CA1 activity using one layer of excitatory cells and one layer of inhibitory cells, with local excitatory-to-inhibitory connectivity, broad inhibitory-to-excitatory connectivity without recurrent excitatory connections, and broad inhibitory-inhibitory connections. The layers need not follow a topographic organization; instead they can represent sequences of place cells structured by local inhibition. Our mathematical model of CA1 neurons with data-inspired connectivity demonstrates place fields sharpened by disinhibition, mimicking a recently discovered decrease in inhibitory input within place fields and matching in vivo patterns of disinhibition. Mathematical analysis of our model suggests the importance of inhibitory-to-excitatory connections in control of place cell firing rate and sparsity. We also demonstrate that a disinhibition-based mechanism of pattern generation is more flexible without recurrent excitation than the recurrent excitation-rich CA3-like model. Finally, we demonstrate disinhibition as an efficient mechanism for internally-generated sequential activity, where the speed of sequential change depends on both input strength and inhibitory-to-excitatory connection strength. Overall, our model suggests that theta time-scale disinhibition is a foundational mechanism of self-organized sequential activity in the CA1 region, and, possibly, in other networks.",
  "abstract_shown": true,
  "affiliations": [
    "NYU Langone"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "L. Green"
    },
    {
      "name": "M. Voroslakos"
    },
    {
      "affs": [
        0
      ],
      "name": "G. Buzsaki"
    },
    {
      "name": "J. RINZEL"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4pqsrc521kgb5.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.08.757765",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.08.757765v1.full",
  "id": "4pqsrc521kgb5",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.08.757765v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ],
    [
      "openalex",
      "2805|Memory and Neural Mechanisms"
    ]
  ],
  "openalex": "W7222022813",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.08.757765v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4pqsrc521kgb5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:27:56Z",
      "native_id": "10.64898/2026.10.08.757765",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.08.757765v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "A disinhibition-based model of CA1 place field sequences",
  "title_text": "A disinhibition-based model of CA1 place field sequences",
  "type": "preprint",
  "updated_at": "2026-10-30T12:27:56Z",
  "url": "https://research.draconitic.com/paper/4pqsrc521kgb5",
  "venue": "bioRxiv",
  "versions": []
}