{
  "abstract": "Background: Food items are contaminated by various substances (e.g. Per- and polyfluoroalkyl substances – PFAS, Polycyclic aromatic hydrocarbons – PAHs, Brominated Flame Retardants – BFRs) throughout their lifecycle. This study investigated the associations between exposure to contaminants originating from food processing/contact materials and hypertension and type 2 diabetes (T2D) risk in the NutriNet-Santé cohort.\n\nMethods: We assessed cumulative time-dependent exposures to 51 food contaminants using repeated 24h-dietary records from 108,758 participants (78.6% women, mean age=42.8y (SD = 14.7)) of the NutriNet-Santé cohort (2009-2024), and quantitative analyses in food matrices from the French total diet study 2 (2006-2009). Associations between contaminant exposures (sex-specific tertiles) and hypertension/T2D incidence were characterized using multivariable Cox proportional hazards models adjusted for known risk factors. Mixtures effects were explored using sparse PLS-Cox models.\n\nResults: During a median 8y follow-up, 1,958 incident hypertension and 1,202 incident T2D cases were ascertained. 12 BFRs (e.g. total BDEs: HRT3 vs. T1=1.12,95%CI[1.04–1.21],ptrend= 0.005), 7 PAHs and 10 PFAS (e.g. PFOS: HRT3 vs. T1=1.15 [1.06-1.25], poverall<0.001) were associated with increased risk of hypertension. 5 BFRs, 2 PAHs (e.g. benzo[b]fluoranthene: HRT3 vs. T1=1.20[1.03-1.39],ptrend=0.02) and 1 PFAS (e.g. PFDS: HRT3 vs. T1=1.30 [1.04-1.63], ptrend=0.03) were associated with higher T2D incidence. Sparse PLS-Cox models identified contaminants mixtures most associated with each outcome.\n\nConclusions: This large prospective cohort study suggests a potential role for food contaminants such as BFRs, in hypertension and T2D etiology, which is consistent with their metabolic disrupting potential suggested by previous in vivo/in vitro studies. If replicated and confirmed in other epidemiological studies, our findings advocate for stronger regulations on these food contaminants.\n\nKey messages: • Some substances found in food contact material and/or generated during food processing might be associated with a higher risk of hypertension and type 2 diabetes.\n\n• If corroborated by further studies, our study underscores the necessity for stricter regulations on food contaminants.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "abstract",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "X Le Folcalvez"
    },
    {
      "name": "A Hasenböhler"
    },
    {
      "name": "M Payen de la Garanderie"
    },
    {
      "name": "S Shah"
    },
    {
      "name": "X Coumoul"
    },
    {
      "name": "JB Fini"
    },
    {
      "name": "J Muncke"
    },
    {
      "name": "M Deschasaux-Tanguy"
    },
    {
      "name": "B Srour"
    },
    {
      "name": "M Touvier"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4pxr07yrfyrxw.bib",
  "cited_by": 0,
  "doi": "10.1093/eurpub/ckag169.554",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13698883/",
  "id": "4pxr07yrfyrxw",
  "issns": [
    "1101-1262",
    "1464-360X"
  ],
  "landing_url": "https://doi.org/10.1093/eurpub/ckag169.554",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "3. PARALLEL PROGRAMME"
    ],
    [
      "heading",
      "AcademicSubjects/MED00860"
    ],
    [
      "heading",
      "AcademicSubjects/SOC01210"
    ],
    [
      "heading",
      "AcademicSubjects/SOC02610"
    ],
    [
      "openalex",
      "2307|Toxic Organic Pollutants Impact"
    ]
  ],
  "openalex": "W7223653584",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13698883/pdf/?tool=EBI",
  "pmcid": "PMC13698883",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/4pxr07yrfyrxw.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:35Z",
      "native_id": "PMC13698883",
      "source": "pmc",
      "url": "https://doi.org/10.1093/eurpub/ckag169.554"
    },
    {
      "first_seen": "2026-10-30T12:21:34Z",
      "native_id": "PMC:PMC13698883",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13698883"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2307|Toxic Organic Pollutants Impact",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Food processing/contact materials and hypertension/type 2 diabetes risk – NutriNet-Santé cohort",
  "title_text": "Food processing/contact materials and hypertension/type 2 diabetes risk – NutriNet-Santé cohort",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:35:32Z",
  "url": "https://research.draconitic.com/paper/4pxr07yrfyrxw",
  "venue": "The European Journal of Public Health",
  "versions": []
}