{
  "abstract": "Background: This study synthesized published meta-analyses to assess the quality, bias, and strength of evidence regarding mortality risk factors in patients with atrial fibrillation (AF).\n\nMethods: Web of Science, Embase, PubMed, and Cochrane database were used to search the literature up to May 2025. Eligible studies were systematic reviews or meta-analyses investigating AF-related mortality risk factors. AMSTAR tool was used to assess methodological quality and GRADE was used to evaluate evidence certainty.\n\nResults: A total of 216 risk factors were identified. Among them, 86 showed significant associations with mortality, while 130 did not. Based on GRADE ratings, 11 were high-quality significant factors, and 9 were of moderate-quality. Factors linked to increased mortality included certain medications (digoxin, dronedarone, sotalol; warfarin/VKA vs. NOAC was associated with higher mortality), comorbidities (cancer, COPD, diabetes, anemia, frailty, LVH, peripheral artery disease), demographic characteristics (older age, smoking, BMI <18.5, Latin American ethnicity), and AF subtype (persistent or non-paroxysmal). In contrast, reduced mortality was associated with NOAC or DOAC use, higher BMI (25–30 or ≥30), surgical interventions (catheter ablation, LAAC/LAAO), other medications (SGLT2 inhibitors, statins), and early rhythm control.\n\nConclusion: This review highlights key factors associated with mortality in AF. Increased risk was observed with warfarin/VKA use (vs. NOAC), certain antiarrhythmic drugs, comorbidities, low BMI, older age, smoking, and non-paroxysmal AF. In contrast, NOAC use, surgical interventions, high BMI, statin and SGLT2 inhibitor therapy, and early rhythm-control strategies were linked to reduced mortality risk.\n\nSystematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024533372 , PROSPERO CRD42024533372",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiology, Changhai Hospital, Naval Medical University"
  ],
  "article_type": "systematic review",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jin Luo"
    },
    {
      "affs": [
        0
      ],
      "name": "Yunpu Niu"
    },
    {
      "affs": [
        0
      ],
      "name": "Ming Ni"
    },
    {
      "affs": [
        0
      ],
      "name": "Jingyu Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhifu Guo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4qg4vjf31y39z.bib",
  "cited_by": 0,
  "doi": "10.3389/fcvm.2026.1877770",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710006/",
  "id": "4qg4vjf31y39z",
  "issns": [
    "2297-055X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fcvm.2026.1877770/full",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Systematic Review"
    ],
    [
      "openalex",
      "2705|Atrial Fibrillation Management and Outcomes"
    ]
  ],
  "openalex": "W7221685961",
  "pdf_url": "https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1877770/pdf",
  "pmcid": "PMC13710006",
  "pmid": "42947670",
  "published": "2026-10-13",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/4qg4vjf31y39z.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "10.3389/fcvm.2026.1877770",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fcvm.2026.1877770/full"
    },
    {
      "first_seen": "2026-10-31T12:21:03Z",
      "native_id": "PMC13710006",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fcvm.2026.1877770"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Atrial Fibrillation Management and Outcomes",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Factors associated with mortality in patients with atrial fibrillation: an umbrella review of systematic reviews and meta-analyses",
  "title_text": "Factors associated with mortality in patients with atrial fibrillation: an umbrella review of systematic reviews and meta-analyses",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:03Z",
  "url": "https://research.draconitic.com/paper/4qg4vjf31y39z",
  "venue": "Frontiers in Cardiovascular Medicine",
  "versions": []
}