{
  "abstract": "神经炎症是物质成瘾发生发展及戒断后复吸的重要病理机制。成瘾物质反复暴露可通过神经元损伤、氧化应激、模式识别受体及炎症小体等途径激活小胶质细胞和星形胶质细胞，从而导致谷氨酸稳态失衡、突触修剪异常及突触可塑性改变，进而影响奖赏、应激和执行功能相关神经环路。与此同时，血脑屏障通透性改变、脑膜免疫反应异常、胶质淋巴系统清除障碍及脑-肠轴失衡可促进中枢与外周免疫信号异常互作并维持炎症状态。精神兴奋剂、阿片类物质和酒精诱发神经炎症的起始机制各具特点，但最终均可引起胶质细胞反应、突触稳态失衡和成瘾相关行为改变。本文阐述了物质成瘾中神经炎症发生的机制，并总结免疫靶向干预的研究进展和临床转化面临的挑战。",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "佳慧 周",
      "orcid": "0009-0008-1633-3383"
    },
    {
      "name": "芝婷 邹"
    },
    {
      "name": "统鹤 潘"
    },
    {
      "name": "昱 刘",
      "orcid": "0000-0002-7581-5939"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4qxyvbb33sa2j.bib",
  "cited_by": 0,
  "doi": "10.3724/zdxbyxb-2026-0195",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13722850/",
  "id": "4qxyvbb33sa2j",
  "issns": [
    "1008-9292"
  ],
  "landing_url": "https://doi.org/10.3724/zdxbyxb-2026-0195",
  "language": "zh",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Monographic Reports"
    ],
    [
      "heading",
      "R749"
    ],
    [
      "heading",
      "R96"
    ],
    [
      "heading",
      "a"
    ],
    [
      "openalex",
      "2808|Neuroinflammation and Neurodegeneration Mechanisms"
    ]
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  "openalex": "W7213363361",
  "pdf_url": null,
  "pmcid": "PMC13722850",
  "pmid": "42778520",
  "published": "2026-09-15",
  "publisher": "Zhejiang University Press",
  "ris": "https://research.draconitic.com/paper/4qxyvbb33sa2j.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:36Z",
      "native_id": "PMC13722850",
      "source": "pmc",
      "url": "https://doi.org/10.3724/zdxbyxb-2026-0195"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2808|Neuroinflammation and Neurodegeneration Mechanisms",
      "subfield": "neurology"
    }
  ],
  "title": "物质成瘾的神经炎症机制研究进展",
  "title_text": "物质成瘾的神经炎症机制研究进展",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:36Z",
  "url": "https://research.draconitic.com/paper/4qxyvbb33sa2j",
  "venue": "Journal of Zhejiang University (Medical Sciences)",
  "versions": []
}