{
  "abstract": "Introduction: Rectal colonization with multidrug-resistant organisms (MDROs) represents a frequent issue in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) for acute leukemia. However, the prognostic significance of MDRO-colonization in these patients remains debated.\n\nMethods: This retrospective, longitudinal, single-center study included 100 patients with acute myeloid or lymphoblastic leukemia treated at Verona University Hospital from diagnosis to allo-HSCT. MDRO-colonization was monitored by rectal swab at admission and weekly during hospitalization. Colonized patients underwent targeted antibiotic therapy when clinically required.\n\nAim of the study: To assess epidemiology, timing, and impact of rectal MDRO-colonization on infection occurrence, infection-related mortality (IRM) within day +100, overall survival (OS), and transplant-related mortality (TRM).\n\nResults: Rectal colonization with 44 MDRO strains was detected in 35 (35%) patients undergoing allo-HSCT, either at hospital admission (45.7%) or during hospitalization (54.3%). Enterobacterales accounted for 72.7% of MDROs, with 68.5% of colonizing strains being detected during previous hospital stays for induction or consolidation therapies. MDRO-related bloodstream infections (BSI) occurred in 9 (9%) patients, 7 (77.8%) of whom being rectal carriers. IRM within day +100 was null. OS was significantly lower in MDRO-carriers as compared to non-carriers only at univariate analysis. TRM did not differ significantly between the two groups in both univariate and multivariate analyses.\n\nConclusion: Despite the limitations of a single-center retrospective study, our data show that careful monitoring of rectal colonization and prompt use of targeted antibiotics may temper the negative impact of MDRO-related infections in adult acute leukemia patients undergoing allo-HSCT, even in the setting of a higher rate of BSIs.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Engineering for Innovation Medicine, Innovation Biomedicine Section, Hematology and Bone Marrow Transplant Unit, University of Verona , ,",
    "Department of Neuroscience, Biomedicine and Movement Sciences, Psychiatry Section, University of Verona , ,",
    "Department of Diagnostics and Public Health, Microbiology Section, University of Verona , ,",
    "Department of Diagnostics and Public Health, Infective Disease Section, University of Verona , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Edoardo Tamellini"
    },
    {
      "affs": [
        1
      ],
      "name": "Chiara Bonetto"
    },
    {
      "affs": [
        2
      ],
      "name": "Annarita Mazzariol"
    },
    {
      "affs": [
        3
      ],
      "name": "Fulvia Mazzaferri"
    },
    {
      "affs": [
        2
      ],
      "name": "Erica Diani"
    },
    {
      "affs": [
        2
      ],
      "name": "Francesca Tolio"
    },
    {
      "affs": [
        0
      ],
      "name": "Sara Pagnin"
    },
    {
      "affs": [
        0
      ],
      "name": "Alessandra Vatteroni"
    },
    {
      "affs": [
        0
      ],
      "name": "Angela Crema"
    },
    {
      "affs": [
        0
      ],
      "name": "Alberto Schena"
    },
    {
      "affs": [
        0
      ],
      "name": "Cristina Tecchio"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4r8b6n9t9tdmw.bib",
  "cited_by": 0,
  "doi": "10.3389/fcimb.2026.1902132",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13719380/?tool=EBI",
  "id": "4r8b6n9t9tdmw",
  "issns": [
    "2235-2988"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13719380",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2730|Neutropenia and Cancer Infections"
    ]
  ],
  "openalex": "W7222761638",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13719380/pdf/?tool=EBI",
  "pmcid": "PMC13719380",
  "pmid": "42964188",
  "published": "2026-10-16",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/4r8b6n9t9tdmw.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:36Z",
      "native_id": "PMC:PMC13719380",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13719380"
    },
    {
      "first_seen": "2026-11-02T12:23:21Z",
      "native_id": "PMC13719380",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fcimb.2026.1902132"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Neutropenia and Cancer Infections",
      "subfield": "oncology"
    }
  ],
  "title": "Rectal colonization with multidrug-resistant organisms in adult acute leukemia patients undergoing allogeneic hematopoietic stem cell transplantation: a retrospective, longitudinal, single-center study",
  "title_text": "Rectal colonization with multidrug-resistant organisms in adult acute leukemia patients undergoing allogeneic hematopoietic stem cell transplantation: a retrospective, longitudinal, single-center study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:20:27Z",
  "url": "https://research.draconitic.com/paper/4r8b6n9t9tdmw",
  "venue": "Frontiers in cellular and infection microbiology",
  "versions": []
}