{
  "abstract": "Objectives: To assess the feasibility of one-stop multi-energy dynamic volume perfusion photon-counting CT (VP-PCCT) for hepatocellular carcinoma (HCC) evaluation, including lesion detection and correlations with histopathology.\n\nMaterials and methods: From July 2024 to June 2025, 407 participants with suspected malignant liver lesions prospectively underwent VP-PCCT, and 177 patients with pathology-confirmed HCC who received three-phase energy-integrating detector CT (EID-CT) were retrospectively enrolled for comparisons of image quality and lesion detectability. Single-phase images reconstructed from VP-PCCT perfusion datasets were compared with EID-CT. Perfusion parameters were analyzed between groups stratified separately by histological grade and microvascular invasion (MVI), and logistic regression was employed to identify independent indicators.\n\nResults: Ninety-two participants [median age, 62 years (IQR, 53–69); 76 males] with pathology-confirmed HCC were included in the VP-PCCT group and matched with 92 in the EID-CT group. Compared with EID-CT, 40-keV VP-PCCT provided comparable image quality for HCC and vessels with a similar tumor detection rate but a lower radiation dose. Poorly-differentiated HCCs showed higher tumor hepatic perfusion index (HPI tumor ) and peritumoral blood flow (BF peritumor ); MVI-positive HCCs exhibited lower tumor arterial liver perfusion (ALP tumor ) and normalized blood flow of peritumoral region (BF norm_peritumor ) (all p < 0.05). HPI tumor [odds ratio (OR): 1.06] and BF peritumor (OR: 1.04) were independent risk factors for poorly differentiated HCC, whereas decreased ALP tumor (OR: 0.97) and BF norm_peritumor (OR: 0.25) were associated with MVI positivity (all p < 0.05).\n\nConclusions: One-stop VP-PCCT delivers high-quality morphologic and perfusion evaluation in a single low-dose scan, with hemodynamic profiles that may be associated with histological grade and MVI status.\n\nKey Points: Question Clinical use of dynamic volume perfusion CT for comprehensively evaluating HCC without additional multiphase contrast-enhanced imaging remains limited.\n\nFindings Multi-energy dynamic photon-counting perfusion CT provided high-quality morphologic imaging of HCC at a low dose, with perfusion parameters independently indicating poorly differentiated HCC and MVI.\n\nCritical relevance statement One-stop multi-energy dynamic photon-counting perfusion CT enables high-quality morphologic and functional assessment in a single low-dose scan, providing comprehensive HCC evaluation with hemodynamic profiling that may support the assessment of histological grade and MVI.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "name": "Huimin Lin",
      "orcid": "0009-0007-8181-5277"
    },
    {
      "name": "Jiahao Zhou"
    },
    {
      "name": "Rong Deng"
    },
    {
      "name": "Zhihan Xu"
    },
    {
      "name": "Yuchen Yang"
    },
    {
      "name": "Yongjun Chen"
    },
    {
      "name": "Huanhuan Chong"
    },
    {
      "name": "Miao Ruan"
    },
    {
      "name": "Chunxue Yang"
    },
    {
      "name": "Haipeng Dong"
    },
    {
      "name": "Rui Chang"
    },
    {
      "name": "Ruokun Li"
    },
    {
      "name": "Weixia Li"
    },
    {
      "name": "Fuhua Yan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4rpzxzy7d0mqt.bib",
  "cited_by": 0,
  "doi": "10.1186/s13244-026-02462-7",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13737244/",
  "id": "4rpzxzy7d0mqt",
  "issns": [
    "1869-4101"
  ],
  "landing_url": "https://link.springer.com/article/10.1186/s13244-026-02462-7",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://link.springer.com/content/pdf/10.1186/s13244-026-02462-7.pdf",
  "pmcid": "PMC13737244",
  "pmid": "42980729",
  "published": "2026-11-04",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/4rpzxzy7d0mqt.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T00:21:14Z",
      "native_id": "10.1186/s13244-026-02462-7",
      "source": "crossref",
      "url": "https://link.springer.com/article/10.1186/s13244-026-02462-7"
    },
    {
      "first_seen": "2026-11-09T12:22:29Z",
      "native_id": "PMC13737244",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s13244-026-02462-7"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:1869-4101",
      "subfield": "imaging"
    }
  ],
  "title": "Feasibility of one-stop multi-energy dynamic photon-counting perfusion CT for resectable HCC evaluation: lesion detection and histopathological correlations",
  "title_text": "Feasibility of one-stop multi-energy dynamic photon-counting perfusion CT for resectable HCC evaluation: lesion detection and histopathological correlations",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:29Z",
  "url": "https://research.draconitic.com/paper/4rpzxzy7d0mqt",
  "venue": "Insights into Imaging",
  "versions": []
}