{
  "abstract": "The etiology of pediatric cancer remains poorly understood and does not fit the classical view as an age-associated genetic disease, suggesting yet unknown mechanisms might be involved. Using high-density native proteome arrays, we analyzed sera from 375 healthy individuals and patients. We found a significant enrichment of autoantibodies against DNA repair proteins shared by cancer patients and healthy children diagnosed with cancer years later. These autoantibodies were detected in multiple cancer types and exhibited remarkable age-specificity. To explore their potential pathogenic significance, we assessed the ability of serum IgG to penetrate live cells. We confirmed that IgG can indeed enter live intact cells and identified a specific pattern of subcellular localization prevalent in pediatric patients. These findings offer a novel direction for the investigation of etiology of pediatric cancer and cancer in general.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical Science, University of Bergen",
    "Department of Global Public Health and Primary Care, University of Bergen",
    "The Norwegian Childhood Cancer Biobank, The Department of Pediatric Oncology and Hematology, Oslo University Hospital",
    "Department of Oncology, Oslo University Hospital",
    "Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital",
    "Western Norway Familial Cancer Center, Haukeland University Hospital"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Anastassia Serguienko"
    },
    {
      "affs": [
        0
      ],
      "name": "Jeetesh Sharma"
    },
    {
      "affs": [
        1
      ],
      "name": "Ronas Shakya"
    },
    {
      "affs": [
        2
      ],
      "name": "Monica Cheng Munthe-Kaas"
    },
    {
      "affs": [
        3
      ],
      "name": "Kjetil Boye"
    },
    {
      "affs": [
        0,
        4,
        5
      ],
      "name": "Ola Myklebost"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4rqz5za31wft3.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1911932",
  "fulltext_url": "https://europepmc.org/articles/PMC13713722",
  "id": "4rqz5za31wft3",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1911932/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2403|T-cell and B-cell Immunology"
    ]
  ],
  "openalex": "W7221817412",
  "pdf_url": "https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1911932/pdf",
  "pmcid": "PMC13713722",
  "pmid": "42953060",
  "published": "2026-10-14",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/4rqz5za31wft3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:17Z",
      "native_id": "10.3389/fimmu.2026.1911932",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1911932/full"
    },
    {
      "first_seen": "2026-10-31T00:20:41Z",
      "native_id": "MED:42953060",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42953060"
    },
    {
      "first_seen": "2026-10-31T12:24:13Z",
      "native_id": "PMC13713722",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fimmu.2026.1911932"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|T-cell and B-cell Immunology",
      "subfield": "immunology"
    }
  ],
  "title": "Pathogenic autoantibodies targeting DNA repair proteins are shared by cancer patients and healthy children later diagnosed with cancer",
  "title_text": "Pathogenic autoantibodies targeting DNA repair proteins are shared by cancer patients and healthy children later diagnosed with cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:20Z",
  "url": "https://research.draconitic.com/paper/4rqz5za31wft3",
  "venue": "Frontiers in Immunology",
  "versions": []
}