{
  "abstract": "We report a new chelating pyridyl–imine ligand bearing a riboflavin-derived pendant group and its Pt(II) complexes 1 and 2, designed as cisplatin- and oxaliplatin-like derivatives. Both complexes reacted with DNA and a histone-derived peptide, with 1 showing markedly higher covalent reactivity. However, this trend was not reflected in biological activity. Complex 2 displayed micromolar antiproliferative effects and pronounced antibacterial activity, particularly against Bacillus subtilis, whereas 1 was inactive in the tested models. Cellular accumulation studies excluded enhanced Pt uptake as the origin of this difference. Fluorescence microscopy performed on Escherichia Coli and Bacillus subtilis indicated that 2 affects bacterial DNA and membrane potential, consistent with a dual antibacterial mechanism. Comparison with oxaliplatin and the free flavin ligands showed that both the Pt–oxalate fragment and the riboflavin-containing ligand are required for activity.",
  "abstract_shown": true,
  "affiliations": [
    "Euskal Herriko Unibertsitatea UPV/EHU, Paseo Manuel de Lardizabal 3, Donostia, Spain, 20018",
    "Donostia International Physics Center, Paseo Manuel de Lardizabal 4, Donostia, Spain, 20018",
    "Institute of Medicinal and Pharmaceutical Chemistry",
    "Technische Universität Braunschweig",
    "Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche, Università degli Studi di Palermo, Viale delle Scienze, Edificio 17, Palermo, Italy, 90128",
    "CNRS, IPREM UMR, 2 Av. du Président Pierre Angot, Pau cedex, France, 64053",
    "Ikerbasque",
    "Basque Foundation for Science"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Maria Jesus Moran Plata",
      "orcid": "0000-0002-4127-8194"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Igor V. Esarev",
      "orcid": "0000-0001-7527-5656"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Nitin Kumar"
    },
    {
      "affs": [
        4
      ],
      "name": "Laura Marretta",
      "orcid": "0009-0009-2852-5427"
    },
    {
      "affs": [
        5
      ],
      "name": "Leo Pontfort"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ana Cristina Carrasco",
      "orcid": "0000-0001-7113-0337"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Beatrice Bernadette Mascitti"
    },
    {
      "affs": [
        4
      ],
      "name": "Alessio Terenzi",
      "orcid": "0000-0001-9751-1373"
    },
    {
      "affs": [
        5
      ],
      "name": "Luisa Ronga",
      "orcid": "0000-0002-8485-6492"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Ingo Ott",
      "orcid": "0000-0002-8087-4618"
    },
    {
      "affs": [
        0,
        1,
        6,
        7
      ],
      "name": "Luca Salassa",
      "orcid": "0000-0002-2112-9095"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4rxfh7jk4gej9.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15009344/v1",
  "fulltext_url": null,
  "id": "4rxfh7jk4gej9",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009344/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Metal complexes synthesis and properties"
    ]
  ],
  "openalex": "W7214099486",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009344/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-23",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/4rxfh7jk4gej9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:21Z",
      "native_id": "10.26434/chemrxiv.15009344",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009344/v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Metal complexes synthesis and properties",
      "subfield": "oncology"
    }
  ],
  "title": "Pt(II)-Flavin Complexes As Anticancer And Antibacterial Agents",
  "title_text": "Pt(II)-Flavin Complexes As Anticancer And Antibacterial Agents",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:21Z",
  "url": "https://research.draconitic.com/paper/4rxfh7jk4gej9",
  "venue": "ChemRxiv",
  "versions": []
}